| Title |
Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review
|
|---|---|
| Published in |
Amino Acids, September 2018
|
| DOI | 10.1007/s00726-018-2658-8 |
| Pubmed ID | |
| Authors |
Henver S. Brunetta, Carolina Q. de Camargo, Everson A. Nunes |
| Abstract |
L-Leucine has been used to improve metabolic outcomes in glucose-intolerant rodent models. However, because studies have used different experimental models and conditions it is difficult to establish the best approach for new clinical trials evaluating the potential effects of L-leucine on glucose homeostasis. We performed a systematic review to report the effect of L-leucine supplementation on glucose homeostasis in rodents with glucose intolerance. The search engines MEDLINE and ScienceDirect were applied using MeSH terms. Thirty-four studies were included in this systematic review. Based on the current data, ingestion of 90-140 mg day-1 of isolated L-leucine in diet-induced obesity (DIO) models shows improvement in metabolic markers if offered during the development of the metabolic disorder in almost all the studies, but not after. Branched-chain amino acid supplementation was effective in streptozotocin-induced β-cells death but not in DIO models. L-Leucine supplementation seems to have an optimal dose and timing for supplementation to improve glucose homeostasis in DIO. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 4 | 12% |
| Other | 3 | 9% |
| Researcher | 3 | 9% |
| Lecturer | 2 | 6% |
| Student > Postgraduate | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 14 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 18% |
| Nursing and Health Professions | 4 | 12% |
| Social Sciences | 2 | 6% |
| Business, Management and Accounting | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 17 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2018.
All research outputs
#15,020,054
of 23,105,443 outputs
Outputs from Amino Acids
#992
of 1,529 outputs
Outputs of similar age
#202,912
of 341,808 outputs
Outputs of similar age from Amino Acids
#11
of 27 outputs
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