Title |
Combined effect of bacteriophage and antibiotic on the inhibition of the development of antibiotic resistance in Salmonella typhimurium
|
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Published in |
Food Science and Biotechnology, March 2018
|
DOI | 10.1007/s10068-018-0351-z |
Pubmed ID | |
Authors |
Kantiya Petsong, Md Jalal Uddin, Kitiya Vongkamjan, Juhee Ahn |
Abstract |
This study was designed to evaluate the combined effects of bacteriophage and antibiotic on the reduction of the development of antibiotic-resistance in Salmonella typhimurium LT2. The susceptibilities of S. typhimurium to ciprofloxacin and erythromycin were increased when treated with bacteriophages, showing more than 10% increase in clear zone sizes and greater than twofold decrease in minimum inhibitory concentration values. The growth of S. typhimurium was effectively inhibited by the combination of bacteriophage P22 and ciprofloxacin. The combination treatment effectively reduced the development of antibiotic resistance in S. typhimurium. The relative expression levels of efflux pump-related genes (acrA, acrB, and tolC) and outer membrane-related genes (ompC, ompD, and ompF) were decreased at all treatments. This study provides useful information for designing new antibiotic therapy to control antibiotic-resistant bacteria. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 3 | 25% |
United States | 1 | 8% |
Mexico | 1 | 8% |
Colombia | 1 | 8% |
Saudi Arabia | 1 | 8% |
Spain | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 11 | 92% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 17% |
Student > Master | 5 | 10% |
Researcher | 4 | 8% |
Student > Ph. D. Student | 4 | 8% |
Professor > Associate Professor | 3 | 6% |
Other | 5 | 10% |
Unknown | 19 | 40% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 9 | 19% |
Agricultural and Biological Sciences | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 3 | 6% |
Unknown | 23 | 48% |