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Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats

Overview of attention for article published in Metabolic Brain Disease, September 2018
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23 Mendeley
Title
Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats
Published in
Metabolic Brain Disease, September 2018
DOI 10.1007/s11011-018-0310-7
Pubmed ID
Authors

Anayelly Solis-Medina, José Jaime Martínez-Magaña, Valeria Quintanar-Jurado, Ileana Gallegos-Silva, Isela E. Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, Juan C Díaz-Zagoya, Yazmín Hernández-Díaz, Thelma Beatriz González-Castro, María Lilia López-Narváez, Alma Delia Genis-Mendoza, Humberto Nicolini

Abstract

Artificial sweeteners are mainly used as substitutes for sucrose derivates. In this study, we analyzed if the chronic consumption of aspartame or acesulfame potassium at an early age, produces histological alterations, astrogliosis and decreased neuronal viability, in hippocampus, prefrontal cortex, amygdala and hypothalamus of male Wistar rats. A histological analysis was performed on male Wistar rats that consumed aspartame or acesulfame potassium during 90 days, initiating the consumption of sweeteners immediately after weaning. The evaluation of neuronal morphology in different areas of the brain was performed with hematoxylin - eosin staining. To measure astrogliosis and neuronal viability, we used the immunohistochemical technique, with the glial fibrillary acidic protein immunomodulators (GFAP) and with neuronal-specific enolase (NSE). The consumption of aspartame or acesulfame potassium promoted morphological changes of neurons including increased pyknotic nuclei and vacuolization in all the brain areas studied. In hippocampus, prefrontal cortex, amygdala and hypothalamus, astrogliosis and reduction of neural viability were observed in sweeteners consumers in comparison with the control group. Chronic consumption of ASP and ACK from early stages of development and during long periods, may promote neural modifications, astrogliosis and decrease neuronal viability in prefrontal cortex, amygdala, hippocampus, and hypothalamus.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Student > Bachelor 3 13%
Student > Master 2 9%
Lecturer 1 4%
Student > Ph. D. Student 1 4%
Other 3 13%
Unknown 9 39%
Readers by discipline Count As %
Neuroscience 4 17%
Agricultural and Biological Sciences 3 13%
Medicine and Dentistry 3 13%
Biochemistry, Genetics and Molecular Biology 1 4%
Physics and Astronomy 1 4%
Other 0 0%
Unknown 11 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2018.
All research outputs
#14,117,129
of 23,067,276 outputs
Outputs from Metabolic Brain Disease
#500
of 1,064 outputs
Outputs of similar age
#183,066
of 341,433 outputs
Outputs of similar age from Metabolic Brain Disease
#6
of 15 outputs
Altmetric has tracked 23,067,276 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,064 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,433 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.