| Title |
Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions
|
|---|---|
| Published in |
Biogerontology, September 2018
|
| DOI | 10.1007/s10522-018-9771-7 |
| Pubmed ID | |
| Authors |
Niharika A. Duggal |
| Abstract |
It is widely accepted that ageing is accompanied by remodelling of the immune system, including reduced numbers of naïve T cells, increased senescent or exhausted T cells, compromise to monocyte, neutrophil and natural killer cell function and an increase in systemic inflammation. In combination these changes result in increased risk of infection, reduced immune memory, reduced immune tolerance and immune surveillance, with significant impacts upon health in old age. More recently it has become clear that the rate of decline in the immune system is malleable and can be influenced by environmental factors such as physical activity as well as pharmacological interventions. This review discusses briefly our current understanding of immunesenescence and then focuses on lifestyle interventions and therapeutic strategies that have been shown to restore immune functioning in aged individuals. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 6 | 11% |
| Mexico | 6 | 11% |
| Colombia | 3 | 5% |
| Argentina | 2 | 4% |
| Paraguay | 2 | 4% |
| Chile | 2 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Germany | 1 | 2% |
| Egypt | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 25 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 51 | 93% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
| Scientists | 1 | 2% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 14% |
| Student > Bachelor | 15 | 14% |
| Researcher | 14 | 13% |
| Student > Ph. D. Student | 12 | 11% |
| Lecturer | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 37 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 19% |
| Immunology and Microbiology | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Neuroscience | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 16 | 15% |
| Unknown | 40 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2022.
All research outputs
#1,076,838
of 25,630,321 outputs
Outputs from Biogerontology
#30
of 725 outputs
Outputs of similar age
#22,921
of 353,511 outputs
Outputs of similar age from Biogerontology
#3
of 11 outputs
Altmetric has tracked 25,630,321 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 725 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,511 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.