| Title |
FOXO transcription factors in cancer development and therapy
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2015
|
| DOI | 10.1007/s00018-015-2112-y |
| Pubmed ID | |
| Authors |
Alexandra Coomans de Brachène, Jean-Baptiste Demoulin |
| Abstract |
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in a limited number of human cancers, such as rhabdomyosarcoma, leukemia and lymphoma. In addition, FOXO proteins are inactivated by major oncogenic signals such as the phosphatidylinositol-3 kinase pathway and MAP kinases. Their expression is also repressed by micro-RNAs in multiple cancer types. FOXOs are mediators of the tumor response to various therapies. However, paradoxical roles of FOXOs in cancer progression were recently described. FOXOs contribute to the maintenance of leukemia-initiating cells in acute and chronic myeloid leukemia. These factors may also promote invasion and metastasis of subsets of colon and breast cancers. Resistance to treatment was also ascribed to FOXO activation in multiple cases, including targeted therapies. In this review, we discuss the complex role of FOXOs in cancer development and response to therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Russia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 145 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 20% |
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 18 | 12% |
| Student > Doctoral Student | 9 | 6% |
| Other | 20 | 13% |
| Unknown | 28 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 61 | 40% |
| Agricultural and Biological Sciences | 21 | 14% |
| Medicine and Dentistry | 17 | 11% |
| Immunology and Microbiology | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 33 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2022.
All research outputs
#4,338,017
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#779
of 4,151 outputs
Outputs of similar age
#70,703
of 392,666 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 49 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,666 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.