Title |
Consensus on management of advanced medullary thyroid carcinoma on behalf of the Working Group of Thyroid Cancer of the Spanish Society of Endocrinology (SEEN) and the Spanish Task Force Group for Orphan and Infrequent Tumors (GETHI)
|
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Published in |
Clinical and Translational Oncology, December 2015
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DOI | 10.1007/s12094-015-1465-x |
Pubmed ID | |
Authors |
E. Grande, J. Santamaría Sandi, J. Capdevila, E. Navarro González, C. Zafón Llopis, T. Ramón y Cajal Asensio, J. M. Gómez Sáez, P. Jiménez-Fonseca, G. Riesco-Eizaguirre, J. C. Galofré |
Abstract |
Of all thyroid cancers, <5 % are medullary (MTC). It is a well-characterized neuroendocrine tumor arising from calcitonin-secreting C cells, and RET gene plays a central role on its pathogeny. The electronic search was conducted using MEDLINE (PubMed), EMBASE and Cochrane Central Register of Controlled Trials. Quality assessments of selected current articles, guidelines and reviews of MTC were performed. This consensus updates and summarizes biology, treatment and prognostic considerations of MTC. Multidisciplinary teams and specialized centers are recommended for the management of MTC patients. In the metastatic setting, those patients with large volume of disease are candidates to start systemic treatment mainly if they are symptomatic and the tumor has progressed in the last 12-14 months. Wait and see strategy should be offered to patients with: disseminated disease with only high levels of calcitonin and no macroscopic structural disease, low burden and absence of progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 25% |
Student > Master | 6 | 14% |
Student > Doctoral Student | 5 | 11% |
Other | 5 | 11% |
Student > Postgraduate | 4 | 9% |
Other | 10 | 23% |
Unknown | 3 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 70% |
Unspecified | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 6 | 14% |