↓ Skip to main content

Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial

Overview of attention for article published in JCEM, December 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
12 X users
video
1 YouTube creator

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
114 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial
Published in
JCEM, December 2015
DOI 10.1210/jc.2015-3696
Pubmed ID
Authors

Hideo Makimura, Takara L Stanley, Caroline Suresh, Ana Luisa De Sousa-Coelho, Walter R Frontera, Stephanie Syu, Laurie R Braun, Sara E Looby, Meghan N Feldpausch, Martin Torriani, Hang Lee, Mary-Elizabeth Patti, Steven K Grinspoon

Abstract

Increased circulating free fatty acids (FFA) have been proposed to contribute to insulin resistance in obesity. Short-term studies have investigated the effects of acipimox, an inhibitor of hormone sensitive lipase, on glucose homeostasis, but longer term studies have not been performed. To test the hypothesis that long term treatment with acipimox would reduce FFA and improve insulin sensitivity among nondiabetic, insulin resistant obese subjects. At an academic medical center, 39 obese men and women were randomized to acipimox 250 mg thrice-daily vs. identical placebo for six months. plasma lipids, insulin sensitivity, adiponectin, and mitochondrial function via assessment of the rate of post-exercise phosphocreatine recovery (PCr) on (31)P-magnetic resonance spectroscopy as well as muscle mitochondrial density and relevant muscle gene expression Results: Fasting glucose decreased significantly in acipimox-treated individuals (effect size -6mg/dL, p=0.02), in parallel with trends for reduced fasting insulin (effect size -6.8 μU/mL, p=0.07) and HOMA-IR (effect size -1.96, p=0.06) and significantly increased adiponectin (effect size +668 ng/mL, p=0.02). Acipimox did not affect insulin-stimulated glucose uptake, as assessed by euglycemic, hyperinsulinemic clamp. Effects on muscle mitochondrial function and density, and relevant gene expression were not seen. These data shed light on the long term effects of FFA reduction on insulin sensitivity, other metabolic parameters, and muscle mitochondrial function in obesity. Reduced FFA achieved by acipimox improved fasting measures of glucose homeostasis, lipids and adiponectin, but had no effect on mitochondrial function, mitochondrial density, or muscle insulin sensitivity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 <1%
Unknown 113 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 12%
Student > Master 11 10%
Researcher 10 9%
Student > Ph. D. Student 10 9%
Professor 6 5%
Other 24 21%
Unknown 39 34%
Readers by discipline Count As %
Medicine and Dentistry 20 18%
Nursing and Health Professions 15 13%
Sports and Recreations 8 7%
Biochemistry, Genetics and Molecular Biology 7 6%
Agricultural and Biological Sciences 5 4%
Other 12 11%
Unknown 47 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2021.
All research outputs
#1,509,320
of 25,373,627 outputs
Outputs from JCEM
#1,134
of 15,431 outputs
Outputs of similar age
#25,163
of 396,009 outputs
Outputs of similar age from JCEM
#17
of 123 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,431 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.