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Assessment of maternal drug intake by urinary bio monitoring during pregnancy and postpartally until the third perinatal year

Overview of attention for article published in Pharmacoepidemiology & Drug Safety, December 2015
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Title
Assessment of maternal drug intake by urinary bio monitoring during pregnancy and postpartally until the third perinatal year
Published in
Pharmacoepidemiology & Drug Safety, December 2015
DOI 10.1002/pds.3943
Pubmed ID
Authors

Henrike Hoeke, Stefan Roeder, Thilo Bertsche, Michael Borte, Martin von Bergen, Dirk K Wissenbach

Abstract

Although sales of prescribed and over-the-counter (OTC) medication are rising, little is known about individual drug intake. This study was aimed to obtain complementary information about drug intake. Information on drug utilization was obtained in a female cohort for five different time points (TP): 36th week of pregnancy (n = 622), 7th perinatal week (n = 533), 3rd perinatal month (n = 340), and 1st perinatal (n = 534) and 3rd perinatal year (n = 324) by a validated urine screening method. Drugs were detected 807 times among all analyzed samples (n = 2353) with less drug intake for early TP compared with later TP (~24.4%, n = 152; ~33.8%, n = 180; ~23.2%, n = 79; ~42.5%, n = 227; and ~52.2%, n = 169). The diversity of drugs increased from 25 up to 40 different drugs for the investigated period. OTC drugs were detected most frequently reflected by the top three drugs: acetaminophen (~37%, n = 292), ibuprofen (~23%, n = 183), and xylometazoline (~12%, n = 98). Mainly guideline-orientated drug therapy was observed. However, contraindicated ibuprofen intake during third trimester urine samples (n = 26) and a repeated usage of acetaminophen and/or ibuprofen (n = 9), as well as xylometazoline (n = 7), reveal missing information about drug safety. Bio monitoring was applied for detection of drug intake revealing a lack of information about OTC products and their health risks. Hence, information about health risks for certain drugs and patient groups must be improved for and by pharmacists, to avoid (i) usage of contraindicated drugs and (ii) abuse of OTC drugs. Copyright © 2015 John Wiley & Sons, Ltd.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Master 5 16%
Student > Bachelor 4 13%
Researcher 3 10%
Professor > Associate Professor 2 6%
Other 3 10%
Unknown 8 26%
Readers by discipline Count As %
Medicine and Dentistry 8 26%
Pharmacology, Toxicology and Pharmaceutical Science 6 19%
Immunology and Microbiology 2 6%
Chemistry 2 6%
Psychology 2 6%
Other 3 10%
Unknown 8 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2015.
All research outputs
#20,723,696
of 25,457,858 outputs
Outputs from Pharmacoepidemiology & Drug Safety
#1,682
of 2,176 outputs
Outputs of similar age
#292,866
of 396,995 outputs
Outputs of similar age from Pharmacoepidemiology & Drug Safety
#46
of 63 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,176 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.