| Title |
Sex hormone replacement in Turner syndrome
|
|---|---|
| Published in |
Endocrine, December 2011
|
| DOI | 10.1007/s12020-011-9569-8 |
| Pubmed ID | |
| Authors |
Christian Trolle, Britta Hjerrild, Line Cleemann, Kristian H. Mortensen, Claus H. Gravholt |
| Abstract |
The cardinal features of Turner syndrome (TS) are short stature, congenital abnormalities, infertility due to gonadal dysgenesis, with sex hormone insufficiency ensuing from premature ovarian failure, which is involved in lack of proper development of secondary sex characteristics and the frequent osteoporosis seen in Turner syndrome. But sex hormone insufficiency is also involved in the increased cardiovascular risk, state of physical fitness, insulin resistance, body composition, and may play a role in the increased incidence of autoimmunity. Severe morbidity and mortality affects females with Turner syndrome. Recent research emphasizes the need for proper sex hormone replacement therapy (HRT) during the entire lifespan of females with TS and new hypotheses concerning estrogen receptors, genetics and the timing of HRT offers valuable new information. In this review, we will discuss the effects of estrogen and androgen insufficiency as well as the effects of sex HRT on morbidity and mortality with special emphasis on evidence based research and areas needing further studies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 21% |
| Student > Ph. D. Student | 18 | 20% |
| Student > Master | 13 | 14% |
| Student > Doctoral Student | 4 | 4% |
| Professor | 4 | 4% |
| Other | 17 | 19% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 51% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Nursing and Health Professions | 5 | 6% |
| Sports and Recreations | 5 | 6% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 7 | 8% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2011.
All research outputs
#15,239,825
of 22,659,164 outputs
Outputs from Endocrine
#938
of 1,675 outputs
Outputs of similar age
#162,657
of 240,804 outputs
Outputs of similar age from Endocrine
#7
of 16 outputs
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