| Title |
Punctate and curvilinear gadolinium enhancing lesions in the brain: a practical approach
|
|---|---|
| Published in |
Neuroradiology, December 2015
|
| DOI | 10.1007/s00234-015-1629-y |
| Pubmed ID | |
| Authors |
Guillaume Taieb, Alberto Duran-Peña, Nicolas Menjot de Chamfleur, Antoine Moulignier, Eric Thouvenot, Thibaut Allou, Arnaud Lacour, Khe Hoang-Xuan, Jean Pelletier, Pierre Labauge |
| Abstract |
Cerebral punctate and curvilinear gadolinium enhancements (PCGE) correspond to opacification of small vessel lumen or its perivascular areas in case of blood-brain barrier (BBB) disruption. We will discuss the possible causes of intra-parenchymal central nervous system PCGE. Our review is based on French database including patients presenting with central nervous system PCGE and literature search using PubMed database with the following keywords: punctate enhancement, linear enhancement, and curvilinear enhancement. Disorders which displayed linear leptomeningeal or periventricular enhancements without intra-parenchymal PCGE are excluded of this review. Among our 39 patients with PCGE, 16 different diagnoses were established. After combining our PCGE causes with those described in the literature, we propose a practical approach. Besides physiologic post-contrast enhancement of small vessels, three pathologic conditions may exhibit PCGE: (1) small collateral artery network seen in Moyamoya syndrome, (2) small veins congestions related to developmental or acquired venous outflow disturbance, and (3) disorders causing small vessels BBB disruption indicated by T2 and FLAIR hyperintensities in the corresponding areas of PCGE. Disruption of the BBB could be caused by a direct injury of the endothelial cell, as in posterior reversible encephalopathy syndrome, Susac syndrome, and radiochemotherapy-induced injuries, or by an angiocentric cellular infiltrate, as in inflammatory disorders, demyelinating diseases, host immune responses fighting against infections, prelymphoma states, lymphoma, and in CLIPPERS. PCGE may conceal several causes, including physiological and pathological conditions. Nevertheless, a practical approach could improve its management and limit the indications of brain biopsy to very specific situations. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 5 | 19% |
| Spain | 2 | 7% |
| United States | 2 | 7% |
| United Kingdom | 1 | 4% |
| Argentina | 1 | 4% |
| Saudi Arabia | 1 | 4% |
| Netherlands | 1 | 4% |
| Iceland | 1 | 4% |
| Colombia | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 9 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 48% |
| Practitioners (doctors, other healthcare professionals) | 9 | 33% |
| Science communicators (journalists, bloggers, editors) | 3 | 11% |
| Scientists | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Unknown | 67 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 17 | 25% |
| Researcher | 10 | 15% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Postgraduate | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Other | 12 | 18% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 59% |
| Neuroscience | 5 | 7% |
| Agricultural and Biological Sciences | 4 | 6% |
| Arts and Humanities | 2 | 3% |
| Sports and Recreations | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 16 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2022.
All research outputs
#1,939,169
of 24,333,504 outputs
Outputs from Neuroradiology
#36
of 1,479 outputs
Outputs of similar age
#33,517
of 399,553 outputs
Outputs of similar age from Neuroradiology
#2
of 17 outputs
Altmetric has tracked 24,333,504 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,479 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.