| Title |
Multiple amino acid substitutions involved in the adaptation of avian-origin influenza A (H10N7) virus in mice
|
|---|---|
| Published in |
Archives of Virology, December 2015
|
| DOI | 10.1007/s00705-015-2722-6 |
| Pubmed ID | |
| Authors |
Haibo Wu, Xiuming Peng, Xiaorong Peng, Linfang Cheng, Changzhong Jin, Xiangyun Lu, Tiansheng Xie, Hangping Yao, Nanping Wu |
| Abstract |
To identify substitutions that are possibly associated with the adaptation of avian-origin H10N7 virus to mammals, adaptation of the H10N7 virus in mouse lung was carried out by serial lung-to-lung passage. Genomic analysis of the mouse-adapted virus revealed amino acid changes in the PB2 (E627K), PA (T97I), and HA (G409E) proteins, and this virus was more virulent in mice than the wild-type virus. Our results suggest that these substitutions are involved in the enhancement of the replication efficiency of avian-origin H10N7 virus, resulting in severe disease in mice. Continued poultry surveillance of these substitutions in H10N7 viruses is required. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 30% |
| Student > Ph. D. Student | 3 | 30% |
| Researcher | 2 | 20% |
| Student > Master | 1 | 10% |
| Professor | 1 | 10% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 20% |
| Veterinary Science and Veterinary Medicine | 1 | 10% |
| Chemical Engineering | 1 | 10% |
| Nursing and Health Professions | 1 | 10% |
| Environmental Science | 1 | 10% |
| Other | 2 | 20% |
| Unknown | 2 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2015.
All research outputs
#18,433,196
of 22,836,570 outputs
Outputs from Archives of Virology
#3,036
of 4,180 outputs
Outputs of similar age
#281,922
of 390,595 outputs
Outputs of similar age from Archives of Virology
#34
of 78 outputs
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