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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit
|
|---|---|
| Published in |
Clinical Infectious Diseases, December 2015
|
| DOI | 10.1093/cid/civ1199 |
| Pubmed ID | |
| Authors |
Alexis Tabah, Menino Osbert Cotta, Jose Garnacho-Montero, Jeroen Schouten, Jason A Roberts, Jeffrey Lipman, Mark Tacey, Jean-François Timsit, Marc Leone, Jean Ralph Zahar, Jan J De Waele |
| Abstract |
De-escalation (DE) is a strategy to reduce the spectrum of antimicrobials and aims to prevent the emergence of bacterial resistance. We present a systematic review describing the definitions, determinants and outcomes associated with DE. We included 2 RCTs and 12 cohort studies. There was considerable variability in the definition of DE. It was more frequently performed in patients with broad-spectrum and/or appropriate antimicrobial therapy (p=0.05 to 0.002), when more agents were used (p=0.002), in the absence of MDR pathogens (p<0.05). Where investigated, lower or improving severity scores were consistently associated with DE (p=0.04 to <0.001). The pooled effect of DE on mortality is protective (RR 0.68, 95% CI 0.52-0.88). As the determinants of DE are markers of clinical improvement and/or of lower risk of treatment failure this effect on mortality cannot be retained as evidence. None of the studies were designed to investigate the effect of DE on antimicrobial resistance. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 16% |
| United Kingdom | 7 | 13% |
| Spain | 5 | 9% |
| South Africa | 3 | 5% |
| Australia | 2 | 4% |
| Canada | 2 | 4% |
| Colombia | 1 | 2% |
| Brazil | 1 | 2% |
| Belgium | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 22 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 60% |
| Scientists | 13 | 24% |
| Practitioners (doctors, other healthcare professionals) | 8 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 237 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| Spain | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 233 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 12% |
| Student > Ph. D. Student | 23 | 10% |
| Other | 20 | 8% |
| Student > Postgraduate | 19 | 8% |
| Student > Master | 19 | 8% |
| Other | 55 | 23% |
| Unknown | 72 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 96 | 41% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 10% |
| Agricultural and Biological Sciences | 9 | 4% |
| Immunology and Microbiology | 6 | 3% |
| Biochemistry, Genetics and Molecular Biology | 6 | 3% |
| Other | 22 | 9% |
| Unknown | 75 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2021.
All research outputs
#942,928
of 26,017,215 outputs
Outputs from Clinical Infectious Diseases
#1,721
of 17,023 outputs
Outputs of similar age
#15,864
of 401,497 outputs
Outputs of similar age from Clinical Infectious Diseases
#11
of 146 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,023 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.