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ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture

Overview of attention for article published in Molecular and Cellular Biochemistry, December 2015
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Title
ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture
Published in
Molecular and Cellular Biochemistry, December 2015
DOI 10.1007/s11010-015-2618-5
Pubmed ID
Authors

Madoka Naemura, Toshiyuki Tsunoda, Yasutoshi Inoue, Haruna Okamoto, Senji Shirasawa, Yojiro Kotake

Abstract

ANRIL is a long noncoding RNA transcribed from the INK4 locus that encodes three tumor suppressor genes, p15, p16, and ARF. Previous studies demonstrated that ANRIL represses p15 and p16, which positively regulate the pRB pathway, leading to repression of cellular senescence of human normal fibroblasts. However, the role of ANRIL in cancer cell proliferation is less well understood. Here we report that ANRIL is involved in the proliferation of colorectal cancer HCT116 cells in two- and three-dimensional culture. Silencing ANRIL by both transfection with small interfering RNA and retrovirally produced small hairpin RNA reduced HCT116 cell proliferation in both two- and three-dimensional culture. HCT116 cells depleted for ANRIL were arrested in the S phase of cell cycle. Notably, silencing ANRIL did not result in the activation of expression of the INK4 locus. These results suggest that ANRIL positively regulates the proliferation of HCT116 cells in two- and three-dimensional culture in a p15/p16-pRB pathway-independent manner.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 38%
Researcher 2 15%
Student > Doctoral Student 2 15%
Lecturer 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 38%
Immunology and Microbiology 2 15%
Medicine and Dentistry 2 15%
Computer Science 1 8%
Agricultural and Biological Sciences 1 8%
Other 1 8%
Unknown 1 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2015.
All research outputs
#18,433,196
of 22,836,570 outputs
Outputs from Molecular and Cellular Biochemistry
#1,564
of 2,307 outputs
Outputs of similar age
#282,576
of 391,336 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#13
of 25 outputs
Altmetric has tracked 22,836,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,307 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 391,336 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.