| Title |
Determining the extent of cholecystectomy using intraoperative specimen ultrasonography in patients with suspected early gallbladder cancer
|
|---|---|
| Published in |
Surgical Endoscopy, December 2015
|
| DOI | 10.1007/s00464-015-4733-5 |
| Pubmed ID | |
| Authors |
Ji Hoon Park, Young Hoon Kim, Haeryoung Kim, Yoo-Seok Yoon, Young Rok Choi, Jai Young Cho, Yoon Jin Lee, Ho-Seong Han |
| Abstract |
Accumulating evidence and guidelines recommend extended cholecystectomy for T1b or greater gallbladder cancers. This study aimed to evaluate the feasibility of intraoperative ultrasonography of a resected gallbladder specimen (specimen US) for the determination of the extent of cholecystectomy. We included 45 patients (34 women; median [interquartile range] age, 66 [57-74] years) who underwent specimen US. After simple laparoscopic cholecystectomy, a gallbladder specimen was examined to evaluate the depth of tumor invasion by specimen US and frozen section examination. With the results of those two examinations, the operating surgeon decided whether to perform extended cholecystectomy. The sensitivity and specificity of specimen US and frozen section examination in diagnosing T1b or greater cancer were, respectively, measured using permanent pathology as the reference standard. The surgeons' final decisions were evaluated in the same manner as the intraoperative examinations. Among 22 patients in whom adenocarcinomas were confirmed, 17 patients had T1b or greater cancers. The sensitivity and specificity of specimen US alone were 81 % (95 % CI, 54-96 %) and 85 % (65-96 %), respectively. The sensitivity and specificity of frozen section examination alone were 43 % (10-82 %) and 95 % (75-100 %), respectively. Except one patient in whom extended cholecystectomy was intentionally not performed, 14 out of 16 patients (88 %; 95 % CI, 62-98 %) who were finally confirmed as having T1b or greater cancers underwent extended cholecystectomy by the surgeons' decision based on both specimen US and frozen examination. Out of 28 patients who were finally confirmed as having benign lesions or T1a cancers, 25 (89 %; 72-98 %) underwent simple cholecystectomy. Specimen US was feasible to be incorporated in clinical practice. Although the diagnostic accuracy of specimen US alone was moderate, the combined use of specimen US and frozen section examination could help the surgeons make correct decisions on the extent of cholecystectomy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 3 | 21% |
| Student > Doctoral Student | 2 | 14% |
| Lecturer > Senior Lecturer | 1 | 7% |
| Student > Bachelor | 1 | 7% |
| Other | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 43% |
| Psychology | 2 | 14% |
| Biochemistry, Genetics and Molecular Biology | 1 | 7% |
| Unknown | 5 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2015.
All research outputs
#18,433,196
of 22,836,570 outputs
Outputs from Surgical Endoscopy
#4,758
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Outputs of similar age
#283,829
of 392,772 outputs
Outputs of similar age from Surgical Endoscopy
#66
of 100 outputs
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