| Title |
Implications of exercise-induced adipo-myokines in bone metabolism
|
|---|---|
| Published in |
Endocrine, December 2015
|
| DOI | 10.1007/s12020-015-0834-0 |
| Pubmed ID | |
| Authors |
Giovanni Lombardi, Fabian Sanchis-Gomar, Silvia Perego, Veronica Sansoni, Giuseppe Banfi |
| Abstract |
Physical inactivity has been recognized, by the World Health Organization as the fourth cause of death (5.5 % worldwide). On the contrary, physical activity (PA) has been associated with improved quality of life and decreased risk of several diseases (i.e., stroke, hypertension, myocardial infarction, obesity, malignancies). Bone turnover is profoundly affected from PA both directly (load degree is the key determinant for BMD) and indirectly through the activation of several endocrine axes. Several molecules, secreted by muscle (myokines) and adipose tissues (adipokines) in response to exercise, are involved in the fine regulation of bone metabolism in response to the energy availability. Furthermore, bone regulates energy metabolism by communicating its energetic needs thanks to osteocalcin which acts on pancreatic β-cells and adipocytes. The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines (i.e., irisin, IL-6, LIF, IGF-I) which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of adipokines (i.e., leptin, visfatin, adiponectin, resistin) sustains these effects as well as improves the whole-body metabolic status. The aim of this review is to highlight the newest findings about the exercise-dependent regulation of these molecules and their role in the fine regulation of bone metabolism. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 33% |
| Germany | 1 | 8% |
| Brazil | 1 | 8% |
| Netherlands | 1 | 8% |
| United Kingdom | 1 | 8% |
| United States | 1 | 8% |
| Unknown | 3 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 58% |
| Scientists | 4 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | <1% |
| Unknown | 165 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 15% |
| Student > Master | 21 | 13% |
| Researcher | 16 | 10% |
| Student > Bachelor | 15 | 9% |
| Student > Doctoral Student | 11 | 7% |
| Other | 38 | 23% |
| Unknown | 40 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 17% |
| Biochemistry, Genetics and Molecular Biology | 26 | 16% |
| Sports and Recreations | 16 | 10% |
| Nursing and Health Professions | 15 | 9% |
| Agricultural and Biological Sciences | 10 | 6% |
| Other | 15 | 9% |
| Unknown | 56 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#6,206,613
of 25,211,948 outputs
Outputs from Endocrine
#374
of 1,900 outputs
Outputs of similar age
#90,996
of 405,973 outputs
Outputs of similar age from Endocrine
#7
of 30 outputs
Altmetric has tracked 25,211,948 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,900 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 80% of its peers.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.