| Title |
The Ki-67 labeling index and lymphatic/venous permeation predict the metastatic potential of rectal neuroendocrine tumors
|
|---|---|
| Published in |
Surgical Endoscopy, December 2015
|
| DOI | 10.1007/s00464-015-4735-3 |
| Pubmed ID | |
| Authors |
Shinya Sugimoto, Kinichi Hotta, Tadakazu Shimoda, Kenichiro Imai, Yuichiro Yamaguchi, Takashi Nakajima, Takuma Oishi, Keita Mori, Kohei Takizawa, Naomi Kakushima, Masaki Tanaka, Noboru Kawata, Hiroyuki Matsubayashi, Hiroyuki Ono |
| Abstract |
Endoscopic resection has been used to treat small rectal neuroendocrine tumors (NETs). However, the indication for additional surgery after endoscopic resection is unclear. The aim of this study was to identify risk factors for rectal NET metastasis and to determine the indication for additional surgery. Fifty-five patients with a total of 57 rectal NETs, treated between October 2003 and January 2013, were retrospectively divided into metastatic (11 lesions) and non-metastatic (46 lesions) groups. Tumor size, central depression, invasion depth, lymphatic and venous permeation, mitotic activity, nuclear abnormality, Ki-67 labeling index, and World Health Organization grading classification (G1 or G2) were compared between the groups. Patients underwent endoscopic submucosal resection with a ligation device, transanal full-thickness surgical resection, or radical surgery. By univariate analysis, the odds ratios (OR) for a Ki-67 labeling index >3.0 %, positive lymphatic or venous permeation, World Health Organization grading classification G2, tumor size >10 mm, submucosal invasion >4000 μm, and central depression were 120 (P < 0.001), 67.6 (P < 0.001), 58.7 (P < 0.001), 9.8 (P = 0.0037), 6.8 (P = 0.012), and 5.7 (P = 0.018), respectively. Multivariate logistic regression analyses showed that vascular permeation (OR 111; P = 0.006) and a Ki-67 labeling index >3.0 % (OR 88; P = 0.012) were independent risk factors for metastasis. The Ki-67 labeling index and lymphatic/venous permeation were reliable predictors of rectal NET metastases. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 26% |
| Researcher | 4 | 11% |
| Student > Ph. D. Student | 3 | 9% |
| Professor > Associate Professor | 2 | 6% |
| Student > Bachelor | 1 | 3% |
| Other | 5 | 14% |
| Unknown | 11 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 57% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Neuroscience | 1 | 3% |
| Psychology | 1 | 3% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2015.
All research outputs
#20,299,108
of 22,836,570 outputs
Outputs from Surgical Endoscopy
#5,650
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Outputs of similar age
#330,200
of 393,178 outputs
Outputs of similar age from Surgical Endoscopy
#80
of 100 outputs
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