Title |
Expression of microRNA-452 via adenoviral vector inhibits non-small cell lung cancer cells proliferation and metastasis
|
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Published in |
Tumor Biology, December 2015
|
DOI | 10.1007/s13277-015-4725-z |
Pubmed ID | |
Authors |
Yongsheng Zhang, Lu Han, Jian Pang, Yang Wang, Fan Feng, Qiyu Jiang |
Abstract |
The microRNA miR-452 has been shown to function as a tumor suppressor. However, the cellular mechanism and potential application of miR-452-mediated cancer suppression remain great unknown. This study aims to identify how miR-452 acts in regulating non-small cell lung cancer (NSCLC) proliferation and metastasis. Expression of miR-452 via adenoviral (Ad) vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460. Our data also shows that miR-452 down-regulates the expression of Bmi-1 as well as pro-survival or anti-apoptosis regulators Survivin, cIAP-1, and cIAP-2. By such gene interference, miR-452 modulates NSCLC cell epithelial-mesenchymal transition (EMT) and further disrupts their migration and invasion. Moreover, miR-452 blocks the activation of PI3K/AKT pathway, which is also required for EMT process. These data reveal that miR-452 treatment could be a novel target or strategy for NSCLC treatment. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 29% |
Lecturer | 1 | 14% |
Professor | 1 | 14% |
Researcher | 1 | 14% |
Professor > Associate Professor | 1 | 14% |
Other | 0 | 0% |
Unknown | 1 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 29% |
Biochemistry, Genetics and Molecular Biology | 2 | 29% |
Veterinary Science and Veterinary Medicine | 1 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
Unknown | 1 | 14% |