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Rat as an animal model for Peyronie's disease research: a review of current methods and the peer-reviewed literature

Overview of attention for article published in International Journal of Impotence Research, July 2011
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Title
Rat as an animal model for Peyronie's disease research: a review of current methods and the peer-reviewed literature
Published in
International Journal of Impotence Research, July 2011
DOI 10.1038/ijir.2011.36
Pubmed ID
Authors

E Chung, L De Young, G B Brock

Abstract

While the exact mechanism of Peyronie's disease (PD) remains an enigma, the pathophysiology of PD is considered to be multifactorial, with interactions of genetic predisposition, trauma, tissue inflammation and aberrant wound healing. A non-systematic review of the existing English language literature pertaining to the use of rodent models in the evaluation of PD was performed using the Medline database. Multiple free-text searches were performed on key words: animal models of PD, transforming growth factor β1 (TGF β1), tunical and/or corporal fibrosis, subtunical injection and penile myofibroblasts. The most frequently reported models of PD can be classified as TGF β1, fibrin and surgical trauma-induced models. In vitro studies using Peyronie's fibroblast culture media have also provided further insights into cellular mechanism of PD. At the present time, the research in PD is hampered by the lack of universally accepted animal model and this is likely attributed to the limited insight into PD mechanisms and the difficulties faced by current animal models to truly represent the complexity and complete spectrum of human disease.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 16%
Student > Bachelor 4 13%
Student > Ph. D. Student 3 10%
Lecturer 2 6%
Professor 2 6%
Other 6 19%
Unknown 9 29%
Readers by discipline Count As %
Medicine and Dentistry 10 32%
Biochemistry, Genetics and Molecular Biology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Unspecified 1 3%
Business, Management and Accounting 1 3%
Other 1 3%
Unknown 13 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2011.
All research outputs
#15,239,825
of 22,659,164 outputs
Outputs from International Journal of Impotence Research
#985
of 1,176 outputs
Outputs of similar age
#84,838
of 119,275 outputs
Outputs of similar age from International Journal of Impotence Research
#5
of 9 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,176 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,275 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.