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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype
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|---|---|
| Published in |
Genetic Epidemiology, October 2018
|
| DOI | 10.1002/gepi.22167 |
| Pubmed ID | |
| Authors |
Ian B. Stanaway, Taryn O. Hall, Elisabeth A. Rosenthal, Melody Palmer, Vivek Naranbhai, Rachel Knevel, Bahram Namjou‐Khales, Robert J. Carroll, Krzysztof Kiryluk, Adam S. Gordon, Jodell Linder, Kayla Marie Howell, Brandy M. Mapes, Frederick T.J. Lin, Yoonjung Yoonie Joo, M. Geoffrey Hayes, Ali G. Gharavi, Sarah A. Pendergrass, Marylyn D. Ritchie, Mariza de Andrade, Damien C. Croteau‐Chonka, Soumya Raychaudhuri, Scott T. Weiss, Matt Lebo, Sami S. Amr, David Carrell, Eric B. Larson, Christopher G. Chute, Laura Jarmila Rasmussen‐Torvik, Megan J. Roy‐Puckelwartz, Patrick Sleiman, Hakon Hakonarson, Rongling Li, Elizabeth W. Karlson, Josh F. Peterson, Iftikhar J. Kullo, Rex Chisholm, Joshua Charles Denny, Gail P. Jarvik, The eMERGE Network, David R. Crosslin |
| Abstract |
The Electronic Medical Records and Genomics (eMERGE) network is a network of medical centers with electronic medical records linked to existing biorepository samples for genomic discovery and genomic medicine research. The network sought to unify the genetic results from 78 Illumina and Affymetrix genotype array batches from 12 contributing medical centers for joint association analysis of 83,717 human participants. In this report, we describe the imputation of eMERGE results and methods to create the unified imputed merged set of genome-wide variant genotype data. We imputed the data using the Michigan Imputation Server, which provides a missing single-nucleotide variant genotype imputation service using the minimac3 imputation algorithm with the Haplotype Reference Consortium genotype reference set. We describe the quality control and filtering steps used in the generation of this data set and suggest generalizable quality thresholds for imputation and phenotype association studies. To test the merged imputed genotype set, we replicated a previously reported chromosome 6 HLA-B herpes zoster (shingles) association and discovered a novel zoster-associated loci in an epigenetic binding site near the terminus of chromosome 3 (3p29). |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 80% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 18% |
| Student > Ph. D. Student | 10 | 15% |
| Student > Bachelor | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 23 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 20% |
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Agricultural and Biological Sciences | 8 | 12% |
| Engineering | 3 | 5% |
| Nursing and Health Professions | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 25 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2018.
All research outputs
#14,608,799
of 25,385,509 outputs
Outputs from Genetic Epidemiology
#419
of 833 outputs
Outputs of similar age
#175,423
of 357,774 outputs
Outputs of similar age from Genetic Epidemiology
#10
of 16 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 833 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,774 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.