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Mendeley readers
Attention Score in Context
| Title |
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
|
|---|---|
| Published in |
Journal of Cell Biology, December 2011
|
| DOI | 10.1083/jcb.201104142 |
| Pubmed ID | |
| Authors |
Jingyi Gong, Zhiqi Sun, Lizhen Wu, Wenyi Xu, Nicole Schieber, Dijin Xu, Guanghou Shui, Hongyuan Yang, Robert G. Parton, Peng Li |
| Abstract |
Lipid droplets (LDs) are dynamic cellular organelles that control many biological processes. However, molecular components determining LD growth are poorly understood. Genetic analysis has indicated that Fsp27, an LD-associated protein, is important in controlling LD size and lipid storage in adipocytes. In this paper, we demonstrate that Fsp27 is focally enriched at the LD-LD contacting site (LDCS). Photobleaching revealed the occurrence of lipid exchange between contacted LDs in wild-type adipocytes and Fsp27-overexpressing cells but not Fsp27-deficient adipocytes. Furthermore, live-cell imaging revealed a unique Fsp27-mediated LD growth process involving a directional net lipid transfer from the smaller to larger LDs at LDCSs, which is in accordance with the biophysical analysis of the internal pressure difference between the contacting LD pair. Thus, we have uncovered a novel molecular mechanism of LD growth mediated by Fsp27. |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Finland | 1 | <1% |
| Czechia | 1 | <1% |
| Canada | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 217 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 24% |
| Researcher | 35 | 16% |
| Student > Master | 32 | 14% |
| Student > Bachelor | 16 | 7% |
| Student > Doctoral Student | 10 | 4% |
| Other | 38 | 17% |
| Unknown | 39 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 76 | 34% |
| Biochemistry, Genetics and Molecular Biology | 63 | 28% |
| Medicine and Dentistry | 12 | 5% |
| Physics and Astronomy | 5 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 19 | 9% |
| Unknown | 43 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2012.
All research outputs
#5,378,711
of 25,373,627 outputs
Outputs from Journal of Cell Biology
#3,676
of 11,939 outputs
Outputs of similar age
#42,053
of 246,644 outputs
Outputs of similar age from Journal of Cell Biology
#19
of 75 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,644 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.