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A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases

Overview of attention for article published in Ticks and Tick-borne Diseases, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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11 X users
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1 patent

Citations

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136 Dimensions

Readers on

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266 Mendeley
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2 CiteULike
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Title
A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases
Published in
Ticks and Tick-borne Diseases, December 2015
DOI 10.1016/j.ttbdis.2015.12.012
Pubmed ID
Authors

A.E. Lew-Tabor, M. Rodriguez Valle

Abstract

The field of reverse vaccinology developed as an outcome of the genome sequence revolution. Following the introduction of live vaccinations in the western world by Edward Jenner in 1798 and the coining of the phrase 'vaccine', in 1881 Pasteur developed a rational design for vaccines. Pasteur proposed that in order to make a vaccine that one should 'isolate, inactivate and inject the microorganism' and these basic rules of vaccinology were largely followed for the next 100 years leading to the elimination of several highly infectious diseases. However, new technologies were needed to conquer many pathogens which could not be eliminated using these traditional technologies. Thus increasingly, computers were used to mine genome sequences to rationally design recombinant vaccines. Several vaccines for bacterial and viral diseases (i.e. meningococcus and HIV) have been developed, however the on-going challenge for parasite vaccines has been due to their comparatively larger genomes. Understanding the immune response is important in reverse vaccinology studies as this knowledge will influence how the genome mining is to be conducted. Vaccine candidates for anaplasmosis, cowdriosis, theileriosis, leishmaniasis, malaria, schistosomiasis, and the cattle tick have been identified using reverse vaccinology approaches. Some challenges for parasite vaccine development include the ability to address antigenic variability as well the understanding of the complex interplay between antibody, mucosal and/or T cell immune responses. To understand the complex parasite interactions with the livestock host, there is the limitation where algorithms for epitope mining using the human genome cannot directly be adapted for bovine, for example the prediction of peptide binding to major histocompatibility complex motifs. As the number of genomes for both hosts and parasites increase, the development of new algorithms for pan-genomic mining will continue to impact the future of parasite and ricketsial (and other tick borne pathogens) disease vaccine development.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 266 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Portugal 1 <1%
Germany 1 <1%
Unknown 263 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 41 15%
Researcher 39 15%
Student > Ph. D. Student 33 12%
Student > Bachelor 33 12%
Student > Doctoral Student 14 5%
Other 39 15%
Unknown 67 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 28%
Biochemistry, Genetics and Molecular Biology 32 12%
Veterinary Science and Veterinary Medicine 25 9%
Immunology and Microbiology 17 6%
Medicine and Dentistry 15 6%
Other 21 8%
Unknown 82 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2023.
All research outputs
#3,754,534
of 25,374,917 outputs
Outputs from Ticks and Tick-borne Diseases
#169
of 1,883 outputs
Outputs of similar age
#60,612
of 394,043 outputs
Outputs of similar age from Ticks and Tick-borne Diseases
#6
of 37 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,883 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.