Title |
Exploring NAD+ metabolism in host–pathogen interactions
|
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Published in |
Cellular and Molecular Life Sciences, December 2015
|
DOI | 10.1007/s00018-015-2119-4 |
Pubmed ID | |
Authors |
Inês Mesquita, Patrícia Varela, Ana Belinha, Joana Gaifem, Mireille Laforge, Baptiste Vergnes, Jérôme Estaquier, Ricardo Silvestre |
Abstract |
Nicotinamide adenine dinucleotide (NAD(+)) is a vital molecule found in all living cells. NAD(+) intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD(+) metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD(+) metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD(+) homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD(+) or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD(+) metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases. |
X Demographics
Geographical breakdown
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Portugal | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 98 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 19% |
Student > Ph. D. Student | 18 | 18% |
Student > Master | 9 | 9% |
Student > Bachelor | 8 | 8% |
Student > Doctoral Student | 7 | 7% |
Other | 17 | 17% |
Unknown | 21 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 22% |
Agricultural and Biological Sciences | 18 | 18% |
Immunology and Microbiology | 17 | 17% |
Chemistry | 6 | 6% |
Medicine and Dentistry | 6 | 6% |
Other | 9 | 9% |
Unknown | 21 | 21% |