| Title |
What is the main mechanism of tramadol?
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, August 2015
|
| DOI | 10.1007/s00210-015-1167-5 |
| Pubmed ID | |
| Authors |
Kouichiro Minami, Junichi Ogata, Yasuhito Uezono |
| Abstract |
Tramadol is an analgesic that is used worldwide for pain, but its mechanisms of action have not been fully elucidated. The majority of studies to date have focused on activation of the μ-opioid receptor (μOR) and inhibition of monoamine reuptake as mechanisms of tramadol. Although it has been speculated that tramadol acts primarily through activation of the μOR, no evidence has revealed whether tramadol directly activates the μOR. During the past decade, major advances have been made in our understanding of the physiology and pharmacology of ion channels and G protein-coupled receptor (GPCR) signaling. Several studies have shown that GPCRs and ion channels are targets for tramadol. In particular, tramadol has been shown to affect GPCRs. Here, the effects of tramadol on GPCRs, monoamine transporters, and ion channels are presented with a discussion of recent research on the mechanisms of tramadol. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 94 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 23% |
| Student > Ph. D. Student | 11 | 12% |
| Other | 10 | 11% |
| Student > Master | 7 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 31 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 27% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 18% |
| Agricultural and Biological Sciences | 5 | 5% |
| Engineering | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Other | 9 | 9% |
| Unknown | 33 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2020.
All research outputs
#7,449,732
of 22,775,504 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#348
of 1,722 outputs
Outputs of similar age
#89,883
of 266,134 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#2
of 9 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,722 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.