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Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines

Overview of attention for article published in Clinical Microbiology and Infection, December 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 X users
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3 Facebook pages

Citations

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49 Dimensions

Readers on

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82 Mendeley
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Title
Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines
Published in
Clinical Microbiology and Infection, December 2015
DOI 10.1016/j.cmi.2015.12.016
Pubmed ID
Authors

C. Solé-Lleonart, J.A. Roberts, J. Chastre, G. Poulakou, L.B. Palmer, S. Blot, T. Felton, M. Bassetti, C.-E. Luyt, J.M. Pereira, J. Riera, T. Welte, H. Qiu, J.-J. Rouby, J. Rello, the ESGCIP Investigators

Abstract

Nebulised antimicrobial agents are increasingly administered for treatment of respiratory infections in mechanically ventilated (MV) patients. A structured online questionnaire assessing the indications, dosages and recent patterns of use for nebulised antimicrobial agents in MV patients was developed. The questionnaire was distributed worldwide and completed by 192 ICUs. The most common indications for using nebulised antimicrobial agent were ventilator-associated tracheobronchitis (VAP; 60/87), ventilator-associated pneumonia (VAT; 58/87) and management of multi-drug resistant Gram negative (58/87) bacilli in the respiratory tract. The most common prescribed nebulised agents were colistin methanesulfonate (CMS) and sulphate (36/87; 41.3% and 24/87; 27.5%), tobramycin (33/87; 37.9%) and amikacin (23/87; 26.4%). CMS, amikacin and tobramycin daily doses for VAP were significantly higher than for VAT (p<0.05). Combination of parenteral and nebulised antibiotics occurred in 36/60 (86%) prescriptions for VAP and 38/58 (66.2%) of prescriptions for VAT. In summary, the use of nebulised antimicrobial agents in MV patients is common. There is marked heterogeneity in clinical practice with significantly different in use between patients with VAP and VAT. Randomised controlled clinical trials and international guidance on indications, dosing and antibiotic combinations to improve clinical outcomes are urgently required.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 1%
Unknown 81 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Postgraduate 11 13%
Other 10 12%
Student > Master 8 10%
Student > Ph. D. Student 7 9%
Other 16 20%
Unknown 17 21%
Readers by discipline Count As %
Medicine and Dentistry 31 38%
Pharmacology, Toxicology and Pharmaceutical Science 9 11%
Immunology and Microbiology 7 9%
Nursing and Health Professions 6 7%
Agricultural and Biological Sciences 3 4%
Other 9 11%
Unknown 17 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2018.
All research outputs
#14,600,874
of 25,374,917 outputs
Outputs from Clinical Microbiology and Infection
#3,033
of 4,641 outputs
Outputs of similar age
#190,893
of 396,505 outputs
Outputs of similar age from Clinical Microbiology and Infection
#40
of 69 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,641 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.