| Title |
RhEPO improves time to exhaustion by non-hematopoietic factors in humans
|
|---|---|
| Published in |
European Journal of Applied Physiology, January 2016
|
| DOI | 10.1007/s00421-015-3322-6 |
| Pubmed ID | |
| Authors |
Simon Annaheim, Matthias Jacob, Alexander Krafft, Christian Breymann, Markus Rehm, Urs Boutellier |
| Abstract |
Erythropoietin (EPO) controls red cell volume (RCV) and plasma volume (PV). Therefore, injecting recombinant human EPO (rhEPO) increases RCV and most likely reduces PV. RhEPO-induced endurance improvements are explained by an increase in blood oxygen (O2) transport capacity, which increases maximum O2 uptake ([Formula: see text]O2max). However, it is debatable whether increased RCV or [Formula: see text]O2max are the main reasons for the prolongation of the time to exhaustion (t lim) at submaximal intensity. We hypothesized that high rhEPO doses in particular contracts PV such that the improvement in t lim is not as strong as at lower doses while [Formula: see text]O2max increases in a dose-dependent manner. We investigated the effects of different doses of rhEPO given during 4 weeks [placebo (P), low (L), medium (M), and high (H) dosage] on RCV, PV, [Formula: see text]O2max and t lim in 40 subjects. While RCV increased in a dose-dependent manner, PV decreased independent of the rhEPO dose. The improvements in t lim (P +21.4 ± 23.8 %; L +16.7 ± 29.8 %; M +44.8 ± 62.7 %; H +69.7 ± 73.4 %) depended on the applied doses (R (2) = 0.89) and clearly exceeded the dose-independent [Formula: see text]O2max increases (P -1.7 ± 3.2 %; L +2.6 ± 6.8 %; M +5.7 ± 5.1 %; H +5.6 ± 4.3 %) after 4 weeks of rhEPO administration. Furthermore, the absolute t lim was not related (R (2) ≈ 0) to RCV or to [Formula: see text]O2max. We conclude that a contraction in PV does not negatively affect t lim and that rhEPO improves t lim by additional, non-hematopoietic factors. |
X Demographics
The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 21% |
| United Kingdom | 6 | 21% |
| Netherlands | 2 | 7% |
| Sweden | 1 | 3% |
| South Africa | 1 | 3% |
| Japan | 1 | 3% |
| France | 1 | 3% |
| Canada | 1 | 3% |
| Jamaica | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 8 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 69% |
| Scientists | 6 | 21% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Netherlands | 1 | 2% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 24% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Master | 7 | 12% |
| Researcher | 6 | 10% |
| Professor | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 14 | 24% |
| Medicine and Dentistry | 9 | 15% |
| Nursing and Health Professions | 8 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 8 | 14% |
| Unknown | 15 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#2,051,421
of 25,373,627 outputs
Outputs from European Journal of Applied Physiology
#670
of 4,345 outputs
Outputs of similar age
#34,247
of 399,776 outputs
Outputs of similar age from European Journal of Applied Physiology
#11
of 37 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,345 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done well, scoring higher than 84% of its peers.
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We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.