| Title |
HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors
|
|---|---|
| Published in |
Molecular Medicine, December 2015
|
| DOI | 10.2119/molmed.2015.00243 |
| Pubmed ID | |
| Authors |
Sergio I. Valdés-Ferrer, Julien Papoin, Meghan E. Dancho, Peder S. Olofsson, Jianhua Li, Jeffrey M. Lipton, Patricia Avancena, Huan Yang, Yong-Rui Zou, Sangeeta S. Chavan, Bruce T. Volpe, Sara Gardenghi, Stefano Rivella, Betty Diamond, Ulf Andersson, Bettie M. Steinberg, Lionel Blanc, Kevin J. Tracey |
| Abstract |
Patients surviving sepsis develop anemia but the molecular mechanism is unknown. Here we observed that mice surviving polymicrobial Gram-negative sepsis develop hypochromic, microcytic anemia with reticulocytosis. The bone marrow of sepsis survivors accumulates polychromatophilic and orthochromatic erythroblasts. Compensatory extramedullary erythropoiesis in the spleen is defective during terminal differentiation. Circulating TNF and IL-6 are elevated for five days after the onset of sepsis, and serum HMGB1 levels are increased from day seven until at least day 28. Administration of recombinant HMGB1 to healthy mice mediates anemia with extramedullary erythropoiesis and significantly elevated reticulocyte counts. Moreover, administration of anti-HMGB1 monoclonal antibodies after sepsis significantly ameliorates the development of anemia (hematocrit 48.5±9.0% versus 37.4±6.1%, p<0.01, hemoglobin 14.0±1.7g/dL versus 11.7±1.2g/dL, p<0.01). Together, these results indicate that HMGB1 mediates anemia by interfering with erythropoiesis, suggesting a potential therapeutic strategy for anemia in sepsis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 17% |
| Professor | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Bachelor | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 15 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 17% |
| Immunology and Microbiology | 5 | 14% |
| Agricultural and Biological Sciences | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Unspecified | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 15 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#6,592,900
of 23,323,574 outputs
Outputs from Molecular Medicine
#319
of 1,162 outputs
Outputs of similar age
#104,782
of 395,307 outputs
Outputs of similar age from Molecular Medicine
#2
of 19 outputs
Altmetric has tracked 23,323,574 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,162 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.