| Title |
Helplessness/hopelessness, minimization and optimism predict survival in women with invasive ovarian cancer: a role for targeted support during initial treatment decision-making?
|
|---|---|
| Published in |
Supportive Care in Cancer, January 2016
|
| DOI | 10.1007/s00520-015-3070-5 |
| Pubmed ID | |
| Authors |
Melanie A. Price, Phyllis N. Butow, Melanie L. Bell, Anna deFazio, Michael Friedlander, Joanna E. Fardell, Melinda M. Protani, Penelope M. Webb, AOCS—Quality of Life Study Investigators on behalf of the Australian Ovarian Cancer Study Group |
| Abstract |
Women with advanced ovarian cancer generally have a poor prognosis but there is significant variability in survival despite similar disease characteristics and treatment regimens. The aim of this study was to determine whether psychosocial factors predict survival in women with ovarian cancer, controlling for potential confounders. The sample comprised 798 women with invasive ovarian cancer recruited into the Australian Ovarian Cancer Study and a subsequent quality of life study. Validated measures of depression, optimism, minimization, helplessness/hopelessness, and social support were completed 3-6 monthly for up to 2 years. Four hundred nineteen women (52.5 %) died over the follow-up period. Associations between time-varying psychosocial variables and survival were tested using adjusted Cox proportional hazard models. There was a significant interaction of psychosocial variables measured prior to first progression and overall survival, with higher optimism (adjusted hazard ratio per 1 standard deviation (HR) = 0.80, 95 % confidence interval (CI) 0.65-0.97), higher minimization (HR = 0.79, CI 0.66-0.94), and lower helplessness/hopelessness (HR = 1.40, CI 1.15-1.71) associated with longer survival. After disease progression, these variables were not associated with survival (optimism HR = 1.10, CI 0.95-1.27; minimization HR = 1.12, CI 0.95-1.31; and helplessness/hopelessness HR = 0.86, CI 0.74-1.00). Depression and social support were not associated with survival. In women with invasive ovarian cancer, psychosocial variables prior to disease progression appear to impact on overall survival, suggesting a preventive rather than modifying role. Addressing psychosocial responses to cancer and their potential impact on treatment decision-making early in the disease trajectory may benefit survival and quality of life. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 27% |
| Luxembourg | 1 | 9% |
| Unknown | 7 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Greece | 1 | 1% |
| Unknown | 68 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 6 | 8% |
| Researcher | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 23 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 20 | 28% |
| Medicine and Dentistry | 12 | 17% |
| Nursing and Health Professions | 6 | 8% |
| Social Sciences | 4 | 6% |
| Business, Management and Accounting | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 24 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2018.
All research outputs
#5,168,040
of 25,345,468 outputs
Outputs from Supportive Care in Cancer
#1,243
of 5,049 outputs
Outputs of similar age
#82,519
of 406,742 outputs
Outputs of similar age from Supportive Care in Cancer
#29
of 74 outputs
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