| Title |
Technical Principles for Protoporphyrin-IX-Fluorescence Guided Microsurgical Resection of Malignant Glioma Tissue
|
|---|---|
| Published in |
Acta Neurochirurgica, October 1998
|
| DOI | 10.1007/s007010050206 |
| Pubmed ID | |
| Authors |
W. Stummer, H. Stepp, G. Möller, A. Ehrhardt, M. Leonhard, H. J. Reulen |
| Abstract |
Malignant gliomas accumulate fluorescing protoporphyrin IX intracellularly after exposure to 5-aminolevulinic acid, a metabolic precursor of haem. This phenomenon has been exploited for intraoperative identification of residual tumour to enable greater completeness of tumour removal. The present report describes the necessary modifications to the operating microscope to enable microsurgical, fluorescence-guided tumour removal. The system consists of a xenon light source coupled to the microscope, which can be switched from normal white light to violet-blue excitation light (375-440 nm). A longpass filter is introduced into the observer light path to enable observation of tumour fluorescence. Transmission characteristics of excitation and observation filters are chosen to transmit part of the remitted excitation light. Thereby the observer retains an impression of tissue detail, next to tumour porphyrin fluorescence. An integrating three chip CCD camera optimized for red light detection enables documentation of fluorescence findings. The present modifications allow uncomplicated and rapid recognition of red tumour fluorescence and its borders to normal tissue, without interrupting the course of the operation. Tissue detail is great enough to enable tumour resection under violet-blue excitation light during parts of the operation. The system appears to constitute a useful tool for optimizing removal of malignant gliomas on a routine basis. |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Nepal | 1 | <1% |
| France | 1 | <1% |
| Hong Kong | 1 | <1% |
| Canada | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 101 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 17% |
| Student > Doctoral Student | 17 | 16% |
| Student > Ph. D. Student | 15 | 14% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 13 | 12% |
| Other | 19 | 18% |
| Unknown | 13 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 42% |
| Engineering | 13 | 12% |
| Agricultural and Biological Sciences | 9 | 8% |
| Neuroscience | 7 | 6% |
| Physics and Astronomy | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 19 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2023.
All research outputs
#2,655,391
of 25,371,288 outputs
Outputs from Acta Neurochirurgica
#87
of 2,141 outputs
Outputs of similar age
#1,516
of 32,088 outputs
Outputs of similar age from Acta Neurochirurgica
#1
of 5 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,141 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 32,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them