| Title |
Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
|
|---|---|
| Published in |
Diabetologia, January 2016
|
| DOI | 10.1007/s00125-015-3854-7 |
| Pubmed ID | |
| Authors |
Lia Bally, Thomas Zueger, Tania Buehler, Ayse S. Dokumaci, Christian Speck, Nicola Pasi, Carlos Ciller, Daniela Paganini, Katrin Feller, Hannah Loher, Robin Rosset, Matthias Wilhelm, Luc Tappy, Chris Boesch, Christoph Stettler |
| Abstract |
To investigate exercise-related fuel metabolism in intermittent high-intensity (IHE) and continuous moderate intensity (CONT) exercise in individuals with type 1 diabetes mellitus. In a prospective randomised open-label cross-over trial twelve male individuals with well-controlled type 1 diabetes underwent a 90 min iso-energetic cycling session at 50% maximal oxygen consumption ([Formula: see text]), with (IHE) or without (CONT) interspersed 10 s sprints every 10 min without insulin adaptation. Euglycaemia was maintained using oral (13)C-labelled glucose. (13)C Magnetic resonance spectroscopy (MRS) served to quantify hepatocellular and intramyocellular glycogen. Measurements of glucose kinetics (stable isotopes), hormones and metabolites complemented the investigation. Glucose and insulin levels were comparable between interventions. Exogenous glucose requirements during the last 30 min of exercise were significantly lower in IHE (p = 0.02). Hepatic glucose output did not differ significantly between interventions, but glucose disposal was significantly lower in IHE (p < 0.05). There was no significant difference in glycogen consumption. Growth hormone, catecholamine and lactate levels were significantly higher in IHE (p < 0.05). IHE in individuals with type 1 diabetes without insulin adaptation reduced exogenous glucose requirements compared with CONT. The difference was not related to increased hepatic glucose output, nor to enhanced muscle glycogen utilisation, but to decreased glucose uptake. The lower glucose disposal in IHE implies a shift towards consumption of alternative substrates. These findings indicate a high flexibility of exercise-related fuel metabolism in type 1 diabetes, and point towards a novel and potentially beneficial role of IHE in these individuals. ClinicalTrials.gov NCT02068638 FUNDING: Swiss National Science Foundation (grant number 320030_149321/) and R&A Scherbarth Foundation (Switzerland). |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 28% |
| United States | 4 | 22% |
| Brazil | 1 | 6% |
| Chile | 1 | 6% |
| Russia | 1 | 6% |
| Unknown | 6 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 61% |
| Scientists | 6 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Indonesia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 169 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 16% |
| Student > Bachelor | 25 | 14% |
| Researcher | 19 | 11% |
| Student > Ph. D. Student | 19 | 11% |
| Student > Doctoral Student | 11 | 6% |
| Other | 28 | 16% |
| Unknown | 44 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 23% |
| Sports and Recreations | 23 | 13% |
| Nursing and Health Professions | 21 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Agricultural and Biological Sciences | 6 | 3% |
| Other | 23 | 13% |
| Unknown | 52 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2016.
All research outputs
#3,128,942
of 25,081,505 outputs
Outputs from Diabetologia
#1,517
of 5,337 outputs
Outputs of similar age
#51,404
of 405,446 outputs
Outputs of similar age from Diabetologia
#15
of 71 outputs
Altmetric has tracked 25,081,505 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,337 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
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We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.