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The comparison of the commonly used surrogates for baseline renal function in acute kidney injury diagnosis and staging

Overview of attention for article published in BMC Nephrology, January 2016
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Title
The comparison of the commonly used surrogates for baseline renal function in acute kidney injury diagnosis and staging
Published in
BMC Nephrology, January 2016
DOI 10.1186/s12882-016-0220-z
Pubmed ID
Authors

Charat Thongprayoon, Wisit Cheungpasitporn, Andrew M. Harrison, Wonngarm Kittanamongkolchai, Patompong Ungprasert, Narat Srivali, Abbasali Akhoundi, Kianoush B. Kashani

Abstract

Baseline serum creatinine (SCr) level is frequently not measured in clinical practice. The aim of this study was to investigate the effect of various methods of baseline SCr determination measurement on accuracy of acute kidney injury (AKI) diagnosis in critically ill patients. This was a retrospective cohort study. All adult intensive care unit (ICU) patients admitted at a tertiary referral hospital from January 1, 2011 through December 31, 2011, with at least one measured SCr value during ICU stay, were included in this study. The baseline SCr was considered either an admission SCr (SCrADM) or an estimated SCr, using MDRD formula, based on an assumed glomerular filtration rate (GFR) of 75 ml/min/1.73 m(2) (SCrGFR-75). Determination of AKI was based on the KDIGO SCr criterion. Propensity score to predict the likelihood of missing SCr was used to generate a simulated cohort of 3566 patients with baseline outpatient SCr, who had similar characteristics with patients whose outpatient SCr was not available. Of 7772 patients, 3504 (45.1 %) did not have baseline outpatient SCr. Among patients without baseline outpatient SCr, AKI was detected in 571 (16.3 %) using the SCrADM and 997 (28.4 %) using SCrGFR-75 (p < .001). Compared with non-AKI patients, patients who met AKI only by SCrADM, but not SCrGFR-75, were significantly associated with 60-day mortality (OR 2.90; 95 % CI 1.66-4.87), whereas patients who met AKI only by SCrGFR-75, but not SCrADM, had a non-significant increase in 60-day mortality risk (OR 1.33; 95 % CI 0.94-1.88). In a simulated cohort of patients with baseline outpatient SCr, SCrGFR-75 yielded a higher sensitivity (77.2 vs. 50.5 %) and lower specificity (87.8 vs. 94.8 %) for the AKI diagnosis in comparison with SCrADM. When baseline outpatient SCr was not available, using SCrGFR-75 as surrogate for baseline SCr was found to be more sensitive but less specific for AKI diagnosis compared with using SCrADM. This resulted in higher incidence of AKI with larger likelihood of false-positive cases.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Italy 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 14%
Professor > Associate Professor 6 14%
Professor 5 12%
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Other 11 26%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 22 51%
Business, Management and Accounting 2 5%
Nursing and Health Professions 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Immunology and Microbiology 1 2%
Other 3 7%
Unknown 13 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2016.
All research outputs
#17,780,575
of 22,837,982 outputs
Outputs from BMC Nephrology
#1,708
of 2,471 outputs
Outputs of similar age
#267,789
of 393,971 outputs
Outputs of similar age from BMC Nephrology
#26
of 33 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,471 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,971 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.