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Modulation of N400 in chronic non-fluent aphasia using low frequency Repetitive Transcranial Magnetic Stimulation (rTMS)

Overview of attention for article published in Brain & Language, August 2010
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Title
Modulation of N400 in chronic non-fluent aphasia using low frequency Repetitive Transcranial Magnetic Stimulation (rTMS)
Published in
Brain & Language, August 2010
DOI 10.1016/j.bandl.2010.07.004
Pubmed ID
Authors

Caroline H.S. Barwood, Bruce E. Murdoch, Brooke-Mai Whelan, David Lloyd, Stephan Riek, John D. O’Sullivan, Alan Coulthard, Andrew Wong

Abstract

Low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) has previously been applied to language homologues in non-fluent populations of persons with aphasia yielding significant improvements in behavioral language function up to 43 months post stimulation. The present study aimed to investigate the electrophysiological correlates associated with the application of rTMS through measurement of the semantic based N400 Event-related brain potentials (ERP) component. Low frequency (1 Hz) rTMS was applied to the anterior portion of the homologue to Broca's area (pars triangularis), for 20 min per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent persons with aphasia, 2-6 years post stroke were stimulated. Six participants were randomly assigned to receive real stimulation and six participants were randomly assigned to receive a blind sham control condition. ERP measures were recorded at baseline, 1 week and 2 months subsequent to stimulation. The findings demonstrate treatment related changes observed in the stimulation group when compared to the placebo control group at 2 months post stimulation indicating neuromodulation of N400 as a result of rTMS. No treatment related changes were identified in the stimulation group, when compared to the sham group from baseline to 1 week post stimulation. The electrophysiological results represent the capacity of rTMS to modulate neural language networks and measures of lexical-semantic function in participants with non-fluent aphasia and suggest that time may be an important factor in brain reorganization subsequent to rTMS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 2%
United States 2 2%
France 1 <1%
Netherlands 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Unknown 124 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 28 21%
Student > Bachelor 28 21%
Researcher 13 10%
Student > Ph. D. Student 11 8%
Professor 8 6%
Other 25 19%
Unknown 19 14%
Readers by discipline Count As %
Psychology 25 19%
Medicine and Dentistry 22 17%
Neuroscience 18 14%
Linguistics 10 8%
Nursing and Health Professions 9 7%
Other 18 14%
Unknown 30 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2016.
All research outputs
#15,168,167
of 25,371,288 outputs
Outputs from Brain & Language
#687
of 1,117 outputs
Outputs of similar age
#81,876
of 104,154 outputs
Outputs of similar age from Brain & Language
#2
of 3 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,117 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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