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Endoplasmic reticulum stress‐mediated upregulation of miR‐29a enhances sensitivity to neuronal apoptosis

Overview of attention for article published in European Journal of Neuroscience, February 2016
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
Endoplasmic reticulum stress‐mediated upregulation of miR‐29a enhances sensitivity to neuronal apoptosis
Published in
European Journal of Neuroscience, February 2016
DOI 10.1111/ejn.13160
Pubmed ID
Authors

Katie Nolan, Franziska Walter, Liam P Tuffy, Simone Poeschel, Ross Gallagher, Stefan Haunsberger, Isabella Bray, Raymond L Stallings, Caoimhín G Concannon, Jochen H M Prehn

Abstract

Disturbance of homeostasis within the ER lumen leads to the accumulation of unfolded and misfolded proteins. This results in the activation of an evolutionary conserved stress response termed ER stress that, if unresolved, induces apoptosis. We previously identified the Bcl-2 homology domain 3 (BH3)-Only Protein Puma as a mediator of ER stress-induced apoptosis in neurons. In the search of alternative contributors to ER stress-induced apoptosis, we noted a downregulation of the anti-apoptotic Bcl-2 family protein Mcl-1 during ER stress in both mouse cortical neurons and human SH-SY5Y neuroblastoma cells. Downregulation of Mcl-1 was associated with an upregulation of microRNA-29a (miR-29a) expression, and subsequent experiments showed that miR-29a targeted the 3' UTR of the anti-apoptotic Bcl-2 family protein, Mcl-1. Inhibition of miR-29a expression using sequence specific antagomirs or the overexpression of Mcl-1 decreased cell death following tunicamycin treatment, while gene silencing of Mcl-1 increased cell death. miR-29a did not alter the signalling branches of the ER stress response, rather its expression was controlled by the ER stress-induced transcription factor activating-transcription-factor-4 (ATF4). Our data demonstrate that the ATF4-mediated upregulation of miR-29a enhances the sensitivity of neurons to ER stress-induced apoptosis. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Student > Ph. D. Student 8 24%
Student > Bachelor 6 18%
Student > Master 2 6%
Other 1 3%
Other 3 9%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 36%
Neuroscience 6 18%
Agricultural and Biological Sciences 4 12%
Medicine and Dentistry 2 6%
Psychology 1 3%
Other 3 9%
Unknown 5 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2017.
All research outputs
#6,260,604
of 24,549,201 outputs
Outputs from European Journal of Neuroscience
#1,975
of 6,057 outputs
Outputs of similar age
#97,969
of 410,117 outputs
Outputs of similar age from European Journal of Neuroscience
#37
of 78 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 6,057 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 410,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.