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Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Overview of attention for article published in Nature Genetics, January 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
19 news outlets
blogs
3 blogs
twitter
14 X users
facebook
2 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
217 Dimensions

Readers on

mendeley
228 Mendeley
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Title
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
Published in
Nature Genetics, January 2016
DOI 10.1038/ng.3482
Pubmed ID
Authors

Jessica N Cooke Bailey, Stephanie J Loomis, Jae H Kang, R Rand Allingham, Puya Gharahkhani, Chiea Chuen Khor, Kathryn P Burdon, Hugues Aschard, Daniel I Chasman, Robert P Igo, Pirro G Hysi, Craig A Glastonbury, Allison Ashley-Koch, Murray Brilliant, Andrew A Brown, Donald L Budenz, Alfonso Buil, Ching-Yu Cheng, Hyon Choi, William G Christen, Gary Curhan, Immaculata De Vivo, John H Fingert, Paul J Foster, Charles Fuchs, Douglas Gaasterland, Terry Gaasterland, Alex W Hewitt, Frank Hu, David J Hunter, Anthony P Khawaja, Richard K Lee, Zheng Li, Paul R Lichter, David A Mackey, Peter McGuffin, Paul Mitchell, Sayoko E Moroi, Shamira A Perera, Keating W Pepper, Qibin Qi, Tony Realini, Julia E Richards, Paul M Ridker, Eric Rimm, Robert Ritch, Marylyn Ritchie, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Yeunjoo E Song, Rulla M Tamimi, Fotis Topouzis, Ananth C Viswanathan, Shefali Setia Verma, Douglas Vollrath, Jie Jin Wang, Nicole Weisschuh, Bernd Wissinger, Gadi Wollstein, Tien Y Wong, Brian L Yaspan, Donald J Zack, Kang Zhang, EPIC-Norfolk Eye Study, Robert N Weinreb, Margaret A Pericak-Vance, Kerrin Small, Christopher J Hammond, Tin Aung, Yutao Liu, Eranga N Vithana, Stuart MacGregor, Jamie E Craig, Peter Kraft, Gareth Howell, Michael A Hauser, Louis R Pasquale, Jonathan L Haines, Janey L Wiggs

Abstract

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from eight independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significantly associated SNPs in two Australian studies (1,252 cases and 2,592 controls), three European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2,543 controls). A meta-analysis of the top SNPs identified three new associated loci: rs35934224[T] in TXNRD2 (odds ratio (OR) = 0.78, P = 4.05 × 10(-11)) encoding a mitochondrial protein required for redox homeostasis; rs7137828[T] in ATXN2 (OR = 1.17, P = 8.73 × 10(-10)); and rs2745572[A] upstream of FOXC1 (OR = 1.17, P = 1.76 × 10(-10)). Using RT-PCR and immunohistochemistry, we show TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head. These results identify new pathways underlying POAG susceptibility and suggest new targets for preventative therapies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 227 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 14%
Student > Ph. D. Student 29 13%
Professor 23 10%
Student > Master 20 9%
Other 13 6%
Other 47 21%
Unknown 63 28%
Readers by discipline Count As %
Medicine and Dentistry 59 26%
Biochemistry, Genetics and Molecular Biology 41 18%
Agricultural and Biological Sciences 27 12%
Neuroscience 12 5%
Sports and Recreations 4 2%
Other 16 7%
Unknown 69 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 163. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2024.
All research outputs
#247,131
of 25,177,382 outputs
Outputs from Nature Genetics
#442
of 7,543 outputs
Outputs of similar age
#4,249
of 407,178 outputs
Outputs of similar age from Nature Genetics
#10
of 69 outputs
Altmetric has tracked 25,177,382 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 407,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.