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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
|
|---|---|
| Published in |
Neurobiology of Aging, January 2016
|
| DOI | 10.1016/j.neurobiolaging.2015.12.023 |
| Pubmed ID | |
| Authors |
Michelle K. Lupton, Lachlan Strike, Narelle K. Hansell, Wei Wen, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Katie L. McMahon, Greig I. de Zubicaray, Amelia A. Assareh, Andrew Simmons, Petroula Proitsi, John F. Powell, Grant W. Montgomery, Derrek P. Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, the Alzheimer's Disease Neuroimaging Initiative, Henry Brodaty, David Ames, Julian N. Trollor, Nicholas G. Martin, Paul M. Thompson, Perminder S. Sachdev, Margaret J. Wright |
| Abstract |
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 33% |
| Australia | 2 | 11% |
| United Kingdom | 2 | 11% |
| Spain | 1 | 6% |
| Germany | 1 | 6% |
| Russia | 1 | 6% |
| Unknown | 5 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 72% |
| Scientists | 3 | 17% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 183 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 18% |
| Student > Ph. D. Student | 27 | 14% |
| Student > Master | 23 | 12% |
| Student > Bachelor | 19 | 10% |
| Student > Doctoral Student | 10 | 5% |
| Other | 38 | 20% |
| Unknown | 38 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 32 | 17% |
| Medicine and Dentistry | 28 | 15% |
| Neuroscience | 27 | 14% |
| Agricultural and Biological Sciences | 16 | 9% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Other | 24 | 13% |
| Unknown | 49 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#1,845,765
of 25,373,627 outputs
Outputs from Neurobiology of Aging
#289
of 4,418 outputs
Outputs of similar age
#31,298
of 400,967 outputs
Outputs of similar age from Neurobiology of Aging
#4
of 84 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,967 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.