| Title |
Liposome Formation Using a Coaxial Turbulent Jet in Co-Flow
|
|---|---|
| Published in |
Pharmaceutical Research, October 2015
|
| DOI | 10.1007/s11095-015-1798-8 |
| Pubmed ID | |
| Authors |
Antonio P. Costa, Xiaoming Xu, Mansoor A. Khan, Diane J. Burgess |
| Abstract |
Liposomes are robust drug delivery systems that have been developed into FDA-approved drug products for several pharmaceutical indications. Direct control in producing liposomes of a particular particle size and particle size distribution is extremely important since liposome size may impact cellular uptake and biodistribution. A device consisting of an injection-port was fabricated to form a coaxial turbulent jet in co-flow that produces liposomes via the ethanol injection method. By altering the injection-port dimensions and flow rates, a fluid flow profile (i.e., flow velocity ratio vs. Reynolds number) was plotted and associated with the polydispersity index of liposomes. Certain flow conditions produced unilamellar, monodispersed liposomes and the mean particle size was controllable from 25 up to >465 nm. The mean liposome size is highly dependent on the Reynolds number of the mixed ethanol/aqueous phase and independent of the flow velocity ratio. The significance of this work is that the Reynolds number is predictive of the liposome particle size, independent of the injection-port dimensions. In addition, a new model describing liposome formation is outlined. The significance of the model is that it relates fluid dynamic properties and lipid-molecule physical properties to the final liposome size. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 25% |
| Student > Master | 8 | 18% |
| Researcher | 7 | 16% |
| Professor | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 8 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 32% |
| Engineering | 7 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Chemistry | 3 | 7% |
| Medicine and Dentistry | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 12 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#20,716,759
of 23,316,003 outputs
Outputs from Pharmaceutical Research
#2,673
of 2,888 outputs
Outputs of similar age
#231,933
of 276,063 outputs
Outputs of similar age from Pharmaceutical Research
#22
of 25 outputs
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