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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
|
|---|---|
| Published in |
Immunity, January 2016
|
| DOI | 10.1016/j.immuni.2015.12.007 |
| Pubmed ID | |
| Authors |
Rebecca B. Delconte, Wei Shi, Priyanka Sathe, Takashi Ushiki, Cyril Seillet, Martina Minnich, Tatiana B. Kolesnik, Lucille C. Rankin, Lisa A. Mielke, Jian-Guo Zhang, Meinrad Busslinger, Mark J. Smyth, Dana S. Hutchinson, Stephen L. Nutt, Sandra E. Nicholson, Warren S. Alexander, Lynn M. Corcoran, Eric Vivier, Gabrielle T. Belz, Sebastian Carotta, Nicholas D. Huntington |
| Abstract |
The inhibitor of DNA binding 2 (Id2) is essential for natural killer (NK) cell development with its canonical role being to antagonize E-protein function and alternate lineage fate. Here we have identified a key role for Id2 in regulating interleukin-15 (IL-15) receptor signaling and homeostasis of NK cells by repressing multiple E-protein target genes including Socs3. Id2 deletion in mature NK cells was incompatible with their homeostasis due to impaired IL-15 receptor signaling and metabolic function and this could be rescued by strong IL-15 receptor stimulation or genetic ablation of Socs3. During NK cell maturation, we observed an inverse correlation between E-protein target genes and Id2. These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| Sweden | 1 | 11% |
| Norway | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | <1% |
| Unknown | 110 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 32% |
| Researcher | 20 | 18% |
| Student > Master | 13 | 12% |
| Student > Doctoral Student | 7 | 6% |
| Student > Bachelor | 6 | 5% |
| Other | 14 | 13% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 34 | 31% |
| Agricultural and Biological Sciences | 24 | 22% |
| Biochemistry, Genetics and Molecular Biology | 16 | 14% |
| Medicine and Dentistry | 7 | 6% |
| Engineering | 3 | 3% |
| Other | 7 | 6% |
| Unknown | 20 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2016.
All research outputs
#654,411
of 25,374,647 outputs
Outputs from Immunity
#573
of 4,815 outputs
Outputs of similar age
#11,543
of 401,522 outputs
Outputs of similar age from Immunity
#7
of 68 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,815 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,522 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.