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Mendeley readers
Attention Score in Context
| Title |
CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk
|
|---|---|
| Published in |
British Journal of Cancer, January 2016
|
| DOI | 10.1038/bjc.2015.443 |
| Pubmed ID | |
| Authors |
Xabier Garcia-Albeniz, Anja Rudolph, Carolyn Hutter, Emily White, Yi Lin, Stephanie A Rosse, Jane C Figueiredo, Tabitha A Harrison, Shuo Jiao, Hermann Brenner, Graham Casey, Thomas J Hudson, Mark Thornquist, Loic Le Marchand, John Potter, Martha L Slattery, Brent Zanke, John A Baron, Bette J Caan, Stephen J Chanock, Sonja I Berndt, Deanna Stelling, Charles S Fuchs, Michael Hoffmeister, Katja Butterbach, Mengmeng Du, W James Gauderman, Marc J Gunter, Mathieu Lemire, Shuji Ogino, Jennifer Lin, Richard B Hayes, Robert W Haile, Robert E Schoen, Greg S Warnick, Mark A Jenkins, Stephen N Thibodeau, Fredrick R Schumacher, Noralane M Lindor, Laurence N Kolonel, John L Hopper, Jian Gong, Daniela Seminara, Bethann M Pflugeisen, Cornelia M Ulrich, Conghui Qu, David Duggan, Michelle Cotterchio, Peter T Campbell, Christopher S Carlson, Polly A Newcomb, Edward Giovannucci, Li Hsu, Andrew T Chan, Ulrike Peters, Jenny Chang-Claude |
| Abstract |
Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT. We included 10 835 postmenopausal women (5419 cases and 5416 controls) from 10 studies. We evaluated use of any MHT, oestrogen-only (E-only) and combined oestrogen-progestogen (E+P) hormone preparations. To test for multiplicative interactions, we applied the empirical Bayes (EB) test as well as the Wald test in conventional case-control logistic regression as primary tests. The Cocktail test was used as secondary test. The EB test identified a significant interaction between rs964293 at 20q13.2/CYP24A1 and E+P (interaction OR (95% CIs)=0.61 (0.52-0.72), P=4.8 × 10(-9)). The secondary analysis also identified this interaction (Cocktail test OR=0.64 (0.52-0.78), P=1.2 × 10(-5) (alpha threshold=3.1 × 10(-4)). The ORs for association between E+P and CRC risk by rs964293 genotype were as follows: C/C, 0.96 (0.61-1.50); A/C, 0.61 (0.39-0.95) and A/A, 0.40 (0.22-0.73), respectively. Our results indicate that rs964293 modifies the association between E+P and CRC risk. The variant is located near CYP24A1, which encodes an enzyme involved in vitamin D metabolism. This novel finding offers additional insight into downstream pathways of CRC etiopathogenesis.British Journal of Cancer advance online publication, 14 January 2016; doi:10.1038/bjc.2015.443 www.bjcancer.com. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 22% |
| Student > Ph. D. Student | 4 | 10% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Student > Bachelor | 3 | 7% |
| Other | 9 | 22% |
| Unknown | 10 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 41% |
| Biochemistry, Genetics and Molecular Biology | 6 | 15% |
| Agricultural and Biological Sciences | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Social Sciences | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 10 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#4,181,804
of 22,840,638 outputs
Outputs from British Journal of Cancer
#2,778
of 10,429 outputs
Outputs of similar age
#72,733
of 395,720 outputs
Outputs of similar age from British Journal of Cancer
#52
of 104 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,429 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.