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Protein Misfolding Diseases

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Cover of 'Protein Misfolding Diseases'

Table of Contents

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    Book Overview
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    Chapter 1 Biophysical and Spectroscopic Methods for Monitoring Protein Misfolding and Amyloid Aggregation
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    Chapter 2 Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates
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    Chapter 3 Vesicle-Based Assays to Study Membrane Interactions of Amyloid Peptides
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    Chapter 4 Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis
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    Chapter 5 A Multipronged Method for Unveiling Subtle Structural–Functional Defects of Mutant Chaperone Molecules Causing Human Chaperonopathies
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    Chapter 6 High-Throughput Microplate-Based Fluorescence Assays for Studying Stochastic Aggregation of Superoxide Dismutase-1
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    Chapter 7 Methods for Structural Analysis of Amyloid Fibrils in Misfolding Diseases
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    Chapter 8 Assays for Light Chain Amyloidosis Formation and Cytotoxicity
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    Chapter 9 Monitoring Aggregate Clearance and Formation in Cell-Based Assays
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    Chapter 10 Monitoring Proteome Stress in Live Cells Using HaloTag-Based Fluorogenic Sensor
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    Chapter 11 Quantification of Protein Aggregates Using Bimolecular Fluorescence Complementation
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    Chapter 12 Screening Protein Aggregation in Cells Using Fluorescent Labels Coupled to Flow Cytometry
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    Chapter 13 Induction of Cu/Zn Superoxide Dismutase (SOD1) Aggregation in Living Cells
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    Chapter 14 A Cell Model for HSP60 Deficiencies: Modeling Different Levels of Chaperonopathies Leading to Oxidative Stress and Mitochondrial Dysfunction
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    Chapter 15 Superresolution Fluorescence Imaging of Mutant Huntingtin Aggregation in Cells
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    Chapter 16 Thermal Shift and Stability Assays of Disease-Related Misfolded Proteins Using Differential Scanning Fluorimetry
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    Chapter 17 Methods to Screen Compounds Against Mutant p53 Misfolding and Aggregation for Cancer Therapeutics
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    Chapter 18 Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases
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    Chapter 19 Constructing Kinetically Controlled Denaturation Isotherms of Folded Proteins Using Denaturant-Pulse Chaperonin Binding
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    Chapter 20 In Vitro Prion Amplification Methodology for Inhibitor Screening
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    Chapter 21 SolubiS: Optimizing Protein Solubility by Minimal Point Mutations
Attention for Chapter 18: Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases
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Chapter title
Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases
Chapter number 18
Book title
Protein Misfolding Diseases
Published by
Humana Press, New York, NY, October 2018
DOI 10.1007/978-1-4939-8820-4_18
Pubmed ID
Book ISBNs
978-1-4939-8819-8, 978-1-4939-8820-4
Authors

Oscar Aubi, Per M. Knappskog, Aurora Martinez

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 11%
Student > Bachelor 1 11%
Student > Ph. D. Student 1 11%
Professor > Associate Professor 1 11%
Student > Postgraduate 1 11%
Other 0 0%
Unknown 4 44%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 22%
Chemistry 2 22%
Agricultural and Biological Sciences 1 11%
Unknown 4 44%