Title |
Role of MicroRNAs in NAFLD/NASH
|
---|---|
Published in |
Digestive Diseases and Sciences, January 2016
|
DOI | 10.1007/s10620-015-4002-4 |
Pubmed ID | |
Authors |
Gyongyi Szabo, Timea Csak |
Abstract |
MicroRNAs (miRNAs) are highly conserved, small, 18-25 nucleotide, non-coding RNAs that regulate gene expression at the post-transcriptional level. Each miRNA can regulate hundreds of target genes, and vice versa each target gene can be regulated by numerous miRNAs, suggesting a very complex network and explaining how miRNAs play pivotal roles in fine-tuning essentially all biological processes in all cell types in the liver. Here, we summarize the current knowledge on the role of miRNAs in the pathogenesis and diagnosis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with an outlook to the broader aspects of metabolic syndrome. Furthermore, we discuss the role of miRNAs as potential biomarkers and therapeutic targets in NAFLD/NASH. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | <1% |
Unknown | 108 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 17% |
Researcher | 19 | 17% |
Student > Bachelor | 17 | 16% |
Student > Master | 11 | 10% |
Student > Postgraduate | 6 | 6% |
Other | 15 | 14% |
Unknown | 22 | 20% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 25 | 23% |
Medicine and Dentistry | 23 | 21% |
Agricultural and Biological Sciences | 16 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Immunology and Microbiology | 3 | 3% |
Other | 10 | 9% |
Unknown | 28 | 26% |