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Understanding the human pedunculopontine nucleus in Parkinson’s disease

Overview of attention for article published in Journal of Neural Transmission, January 2016
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Title
Understanding the human pedunculopontine nucleus in Parkinson’s disease
Published in
Journal of Neural Transmission, January 2016
DOI 10.1007/s00702-016-1505-x
Pubmed ID
Authors

Anders Fytagoridis, Peter A. Silburn, Terry J. Coyne, Wesley Thevathasan

Abstract

This paper presents the Brisbane experience of pedunculopontine nucleus (PPN) deep brain stimulation (DBS) in Parkinson's disease (PD). Clinical outcomes along with studies of the mechanisms and neurophysiology of PPN in PD patients with severe freezing of gait (FoG) and postural imbalance (PI) are summarised and presented. Our results indicate that PPN DBS improves FoG and falls in the relatively uncommon group of PD patients who respond well to medication other than for continuing on time FoG and falls. Our studies indicate that bilateral DBS is more beneficial than unilateral DBS, and that the more caudal region of the PPN seems preferable for stimulation. There is evidence that rapid-release programs for initiation and correction of gait and posture are modulated by the PPN, possibly to some extent independently of the cerebral cortex. These functions were found to be impaired in PD patients with severe FoG/PI, but to some extent corrected by bilateral PPN DBS.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 14%
Student > Master 5 12%
Student > Bachelor 5 12%
Student > Doctoral Student 3 7%
Other 3 7%
Other 9 21%
Unknown 12 28%
Readers by discipline Count As %
Neuroscience 7 16%
Nursing and Health Professions 6 14%
Medicine and Dentistry 5 12%
Agricultural and Biological Sciences 3 7%
Engineering 2 5%
Other 4 9%
Unknown 16 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2016.
All research outputs
#15,354,849
of 22,840,638 outputs
Outputs from Journal of Neural Transmission
#1,257
of 1,767 outputs
Outputs of similar age
#230,393
of 392,526 outputs
Outputs of similar age from Journal of Neural Transmission
#20
of 32 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,767 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,526 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.