Title |
Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis
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Published in |
Diabetologia, October 2015
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DOI | 10.1007/s00125-015-3788-0 |
Pubmed ID | |
Authors |
Min Xu, Xiaofei Lv, Lan Xie, Xiaolin Huang, Ya Huang, Ying Chen, Kui Peng, Po Wang, Weiqing Wang, Lu Qi, Yufang Bi, Yimin Sun, Guang Ning |
Abstract |
Glucokinase regulatory protein gene (GCKR) variant rs780092 is a novel genetic variant associated with serum triacylglycerol (TG) identified in a genome-wide association study in East Asians. We aimed to investigate associations of rs780092 with incident type 2 diabetes and dyslipidaemia, and the longitudinal changes in glucose and lipid levels. A community-based prospective cohort study was conducted at baseline in 2008, including 5,613 non-diabetic participants (37% male, mean age 57.6 years) with 5 years of follow-up. Blood glucose and lipid was measured at baseline and follow-up. Each rs780092 T-allele was associated with a 17% lower risk of incident type 2 diabetes (HR 0.83 [95% CI 0.73, 0.95]) and 36% higher risk of incident hypertriacylglycerolaemia (OR 1.36 [95% CI 1.08, 1.72]), after adjustment for baseline fasting glucose and TG and other confounders. The T-allele was associated with a 5 year increasing level of log10 TG (β ± SE, 0.01 ± 0.004, p = 0.005). Mediation analysis showed that both baseline TG and the 5 year increase in log10 TG were significant mediators in the associations of rs780092 with risk of diabetes. The risk of incident type 2 diabetes associated with 1 SD increase in total and LDL-cholesterol was 35% and 22% lower in TT carriers compared with CC carriers, respectively (both p for interaction ≤ 0.04). The GCKR rs780092 variant showed opposite-directional associations with type 2 diabetes and hypertriacylglycerolaemia in a Chinese population. Both baseline level and 5 year change in serum TG were mediators of the association between the genetic variant and type 2 diabetes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Taiwan | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 20% |
Librarian | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Other | 1 | 7% |
Professor | 1 | 7% |
Other | 1 | 7% |
Unknown | 5 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 20% |
Agricultural and Biological Sciences | 3 | 20% |
Materials Science | 2 | 13% |
Environmental Science | 1 | 7% |
Social Sciences | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |