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X Demographics
Mendeley readers
Attention Score in Context
| Title |
High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly
|
|---|---|
| Published in |
Experimental Gerontology, January 2016
|
| DOI | 10.1016/j.exger.2016.01.005 |
| Pubmed ID | |
| Authors |
Letizia Polito, Tino Emanuele Poloni, Roberta Vaccaro, Simona Abbondanza, Michela Mangieri, Annalisa Davin, Simona Villani, Antonio Guaita |
| Abstract |
High total homocysteine (tHcy) is associated with cognitive impairment in the elderly. The impact of high tHcy on different cognitive domains deserves further investigation, as does the role of the C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene. A cross-sectional analysis of 903 subjects from the population-based "InveCe.Ab" study was performed. The participants had no psychosis or active neurological disorders. They underwent a neuropsychological assessment. Principal component analysis allowed cognitive performance to be condensed into two components: executive functions and memory. Novel components were evaluated for association with tHcy, controlling for potential confounders. Regression models showed that high serum tHcy was associated with lower executive functions, but not with memory. MTHFR C677T TT was associated with higher tHcy but did not affect cognitive performance per se; however, when combined with the apolipoprotein E (APOE)-ε4 allele it was a risk factor for lower executive performance, independently of tHcy levels. High tHcy per se, or MTHFR C677T TT in combination with the APOE-ε4 allele, might be associated primarily with executive dysfunctions rather than memory loss. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 33% |
| United States | 2 | 33% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 1% |
| Canada | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 76 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 16% |
| Student > Master | 11 | 14% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Bachelor | 8 | 10% |
| Professor > Associate Professor | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 19 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 14 | 18% |
| Medicine and Dentistry | 12 | 15% |
| Agricultural and Biological Sciences | 9 | 11% |
| Nursing and Health Professions | 4 | 5% |
| Neuroscience | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 26 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#2,982,964
of 25,373,627 outputs
Outputs from Experimental Gerontology
#460
of 2,796 outputs
Outputs of similar age
#48,661
of 402,343 outputs
Outputs of similar age from Experimental Gerontology
#4
of 34 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,796 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,343 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.