Title |
Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts
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Published in |
Journal of Medical Genetics, December 2011
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DOI | 10.1136/jmedgenet-2011-100427 |
Pubmed ID | |
Authors |
Mark O Goodarzi, Michelle R Jones, Xiaohui Li, Angela K Chua, Obed A Garcia, Yii-Der I Chen, Ronald M Krauss, Jerome I Rotter, Wendy Ankener, Richard S Legro, Ricardo Azziz, Jerome F Strauss, Andrea Dunaif, Margrit Urbanek |
Abstract |
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with a strong familial component. PCOS is characterised by hyperandrogenaemia and irregular menses. A recent genome-wide association study (GWAS) of PCOS in a Chinese cohort identified three reproducible PCOS susceptibility loci mapping to 2p16.3 (luteinising hormone/choriogonadotropin receptor; LHCGR), 2p21 (thyroid associated protein; THADA), and 9q33.3 (DENN/MADD domain containing 1A; DENNDIA). The impact of these loci in non-Chinese PCOS cohorts remains to be determined. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | <1% |
Ukraine | 1 | <1% |
Unknown | 101 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 17% |
Student > Bachelor | 16 | 16% |
Student > Master | 13 | 13% |
Student > Doctoral Student | 9 | 9% |
Researcher | 8 | 8% |
Other | 15 | 15% |
Unknown | 24 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 34 | 33% |
Biochemistry, Genetics and Molecular Biology | 22 | 21% |
Agricultural and Biological Sciences | 11 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Business, Management and Accounting | 2 | 2% |
Other | 9 | 9% |
Unknown | 22 | 21% |