| Title |
Role of APP for dendritic spine formation and stability
|
|---|---|
| Published in |
Experimental Brain Research, November 2011
|
| DOI | 10.1007/s00221-011-2939-x |
| Pubmed ID | |
| Authors |
Christian K. E. Jung, Jochen Herms |
| Abstract |
The amyloid precursor protein (APP) is transported in high amounts to the presynaptic endings where its function is still unknown. Several studies indicate that lack of APP or its overexpression affects the number of dendritic spines, the postsynaptic compartment of excitatory synapses. Since synapse loss has been identified as one of the most important structural correlates of cognitive decline in Alzheimer's diseases (AD), the physiological function of APP at synapses, specifically at dendritic spines, has come into focus in AD research. This review intends to give an overview of the very controversial results on APP expression on dendritic spine number in the mouse brain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 3% |
| Netherlands | 1 | 1% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 65 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 27% |
| Researcher | 19 | 27% |
| Student > Doctoral Student | 6 | 9% |
| Student > Master | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 5 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 49% |
| Biochemistry, Genetics and Molecular Biology | 12 | 17% |
| Medicine and Dentistry | 8 | 11% |
| Neuroscience | 7 | 10% |
| Immunology and Microbiology | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 7 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from Experimental Brain Research
#2,473
of 3,215 outputs
Outputs of similar age
#194,706
of 238,400 outputs
Outputs of similar age from Experimental Brain Research
#28
of 35 outputs
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