Title |
Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia
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Published in |
Future Oncology, January 2016
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DOI | 10.2217/fon.15.326 |
Pubmed ID | |
Authors |
Gail J Roboz, Pau Montesinos, Dominik Selleslag, Andrew Wei, Jun-Ho Jang, Jose Falantes, Maria T Voso, Hamid Sayar, Kimmo Porkka, Paula Marlton, Antonio Almeida, Sanjay Mohan, Farhad Ravandi, Guillermo Garcia-Manero, Barry Skikne, Hagop Kantarjian |
Abstract |
Older patients with acute myeloid leukemia (AML) have worse rates of complete remission and shorter overall survival than younger patients. The epigenetic modifier CC-486 is an oral formulation of azacitidine with promising clinical activity in patients with AML in Phase I studies. The Phase III, randomized, double-blind, placebo-controlled QUAZAR AML Maintenance trial (CC-486-AML-001) examines CC-486 maintenance therapy (300 mg/day for 14 days of 28-day treatment cycles) for patients aged ≥55 years with AML in first complete remission. The primary end point is overall survival. Secondary end points include relapse-free survival, safety, health-related quality of life and healthcare resource utilization. This trial will investigate whether CC-486 maintenance can prolong remission and improve survival for older patients with AML. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Finland | 1 | 1% |
Peru | 1 | 1% |
Unknown | 74 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 20% |
Other | 9 | 12% |
Student > Bachelor | 9 | 12% |
Student > Master | 9 | 12% |
Student > Doctoral Student | 7 | 9% |
Other | 12 | 16% |
Unknown | 15 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 38 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Agricultural and Biological Sciences | 3 | 4% |
Other | 7 | 9% |
Unknown | 18 | 24% |