| Title |
Cyto-Insectotoxin 1a from Lachesana tarabaevi Spider Venom Inhibits Chlamydia trachomatis Infection
|
|---|---|
| Published in |
Probiotics and Antimicrobial Proteins, June 2012
|
| DOI | 10.1007/s12602-012-9108-9 |
| Pubmed ID | |
| Authors |
Nadezhda F. Polina, Marina M. Shkarupeta, Anna S. Popenko, Alexander A. Vassilevski, Sergey A. Kozlov, Eugene V. Grishin, Vassili N. Lazarev, Vadim M. Govorun |
| Abstract |
Venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. Among them, a special place belongs to cyto-insectotoxins, a class of cytolytic molecules showing equally potent antimicrobial and insecticidal effects. We tested one of them, CIT 1a, for ability to suppress Chlamydia trachomatis infection. HEK293 cells were transfected with plasmid vectors harboring the cit 1a gene. Controlled expression of the transgene led to a significant decrease in C. trachomatis viability inside the infected cells. Using proteomic and transcriptomic approaches, we found alterations in protein expression patterns and identified differentially expressed genes in transfected cells. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 24% |
| Professor > Associate Professor | 3 | 18% |
| Other | 2 | 12% |
| Student > Postgraduate | 2 | 12% |
| Student > Master | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 24% |
| Biochemistry, Genetics and Molecular Biology | 2 | 12% |
| Physics and Astronomy | 1 | 6% |
| Unknown | 5 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2016.
All research outputs
#20,302,535
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Outputs from Probiotics and Antimicrobial Proteins
#393
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#147,673
of 163,845 outputs
Outputs of similar age from Probiotics and Antimicrobial Proteins
#1
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