| Title |
Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple Sclerosis
|
|---|---|
| Published in |
Sports Medicine, January 2016
|
| DOI | 10.1007/s40279-016-0472-6 |
| Pubmed ID | |
| Authors |
Rachel E. Klaren, Brian M. Sandroff, Bo Fernhall, Robert W. Motl |
| Abstract |
The study and application of exercise in multiple sclerosis (MS) often requires cardiopulmonary exercise testing (CPET) to provide a comprehensive assessment of exercise tolerance and responses, including an evaluation of the pulmonary, cardiovascular, and skeletal muscle systems. Research on CPET in persons with MS has considerable limitations, including small sample sizes, often without controls; not reporting outcomes across disability status; and different modalities of exercise testing across studies. Although some key outcome variables of CPET have been studied in persons with MS, additional calculated variables have not been directly studied. The objective of this study was to provide a comprehensive examination of outcome variables from CPET among persons with MS and healthy controls. We included data from 162 persons with MS and 80 healthy controls who underwent CPET on a leg ergometer and satisfied criteria for valid testing for measuring oxygen uptake (VO2), carbon dioxide production (VCO2), ventilation (VE), respiratory exchange ratio, work rate, and heart rate (HR). Calculated variables [i.e. ventilatory anaerobic threshold (VO2/VCO2), VE/VCO2 slope, VO2/power slope, VO2/HR slope, and oxygen uptake efficiency slope] were processed using standard guidelines. We examined differences in the CPET variables between groups (e.g. MS vs. controls and categories of mild, moderate, and severe disability status) using analysis of covariance (ANCOVA), controlling for age, sex, body mass index, and disease duration. Overall, persons with MS demonstrate alterations in outcomes from CPET compared with controls, and these are generally exacerbated with increasing disability. Our results provide novel information for the evaluation of CPET in MS for developing exercise prescriptions and documenting adaptations with exercise training based on the comprehensive variables obtained during CPET. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| New Zealand | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 2% |
| Spain | 1 | <1% |
| Unknown | 101 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 17% |
| Student > Bachelor | 16 | 15% |
| Student > Master | 15 | 14% |
| Researcher | 10 | 10% |
| Other | 6 | 6% |
| Other | 16 | 15% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 21 | 20% |
| Medicine and Dentistry | 15 | 14% |
| Nursing and Health Professions | 13 | 13% |
| Psychology | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 34 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2016.
All research outputs
#13,231,393
of 23,317,888 outputs
Outputs from Sports Medicine
#2,309
of 2,735 outputs
Outputs of similar age
#182,864
of 397,600 outputs
Outputs of similar age from Sports Medicine
#62
of 65 outputs
Altmetric has tracked 23,317,888 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,735 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.