| Title |
Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer
|
|---|---|
| Published in |
Medical Oncology, April 2015
|
| DOI | 10.1007/s12032-015-0616-9 |
| Pubmed ID | |
| Authors |
Jianhua Lu, Qian Dong, Bingtai Zhang, Xuefeng Wang, Bin Ye, Fei Zhang, Xiaoling Song, Guofeng Gao, Jiasheng Mu, Zheng Wang, Fei Ma, Jun Gu |
| Abstract |
Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. However, little is known with regard to its expression and biological functions in pancreatic cancer. In this study, we focused on the clinical significance and biological functions of CLIC1 in pancreatic cancer and found that this protein was overexpressed in pancreatic cancer tissues. Patients with CLIC1-positive tumours had worse overall survival than those with CLIC1-negative tumours. Furthermore, the treatment of pancreatic cancer cell lines with CLIC1-targeting siRNA oligonucleotides significantly reduced cell proliferation and diminished anchorage-independent growth on both soft agar and cell migration. These data indicate that CLIC1 acts as a putative oncogene in pancreatic cancer and may represent a novel diagnostic and therapeutic target for pancreatic cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Researcher | 5 | 14% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Other | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 8 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 28% |
| Agricultural and Biological Sciences | 7 | 19% |
| Chemistry | 4 | 11% |
| Immunology and Microbiology | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 10 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2016.
All research outputs
#20,302,535
of 22,840,638 outputs
Outputs from Medical Oncology
#959
of 1,294 outputs
Outputs of similar age
#223,440
of 265,033 outputs
Outputs of similar age from Medical Oncology
#21
of 31 outputs
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