Title |
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers
|
---|---|
Published in |
New England Journal of Medicine, December 2011
|
DOI | 10.1056/nejmoa1102903 |
Pubmed ID | |
Authors |
Alireza Heravi-Moussavi, Michael S Anglesio, S-W Grace Cheng, Janine Senz, Winnie Yang, Leah Prentice, Anthony P Fejes, Christine Chow, Alicia Tone, Steve E Kalloger, Nancy Hamel, Andrew Roth, Gavin Ha, Adrian N C Wan, Sarah Maines-Bandiera, Clara Salamanca, Barbara Pasini, Blaise A Clarke, Anna F Lee, Cheng-Han Lee, Chengquan Zhao, Robert H Young, Samuel A Aparicio, Poul H B Sorensen, Michelle M M Woo, Niki Boyd, Steven J M Jones, Martin Hirst, Marco A Marra, Blake Gilks, Sohrab P Shah, William D Foulkes, Gregg B Morin, David G Huntsman |
Abstract |
Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 32% |
Mexico | 1 | 3% |
Panama | 1 | 3% |
Belgium | 1 | 3% |
Comoros | 1 | 3% |
Egypt | 1 | 3% |
Norway | 1 | 3% |
France | 1 | 3% |
Unknown | 14 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 23 | 74% |
Scientists | 5 | 16% |
Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 4% |
United Kingdom | 3 | 2% |
Canada | 3 | 2% |
Brazil | 2 | 1% |
Germany | 1 | <1% |
Greece | 1 | <1% |
Japan | 1 | <1% |
Unknown | 181 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 41 | 21% |
Student > Ph. D. Student | 34 | 17% |
Student > Master | 24 | 12% |
Student > Bachelor | 21 | 11% |
Other | 11 | 6% |
Other | 29 | 15% |
Unknown | 39 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 64 | 32% |
Agricultural and Biological Sciences | 39 | 20% |
Biochemistry, Genetics and Molecular Biology | 33 | 17% |
Nursing and Health Professions | 3 | 2% |
Engineering | 3 | 2% |
Other | 12 | 6% |
Unknown | 45 | 23% |