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Effects of a food supplement rich in arginine in patients with smear positive pulmonary tuberculosis – A randomised trial

Overview of attention for article published in Tuberculosis (formerly Tubercle and Lung Disease), August 2011
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1 Wikipedia page

Citations

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39 Dimensions

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116 Mendeley
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Title
Effects of a food supplement rich in arginine in patients with smear positive pulmonary tuberculosis – A randomised trial
Published in
Tuberculosis (formerly Tubercle and Lung Disease), August 2011
DOI 10.1016/j.tube.2011.06.002
Pubmed ID
Authors

T. Schön, J. Idh, A. Westman, D. Elias, E. Abate, E. Diro, F. Moges, A. Kassu, B. Ayele, T. Forslund, A. Getachew, S. Britton, O. Stendahl, T. Sundqvist

Abstract

In tuberculosis (TB), the production of nitric oxide (NO) is confirmed but its importance in host defense is debated. Our aim was to investigate whether a food supplement rich in arginine could enhance clinical improvement in TB patients by increased NO production. Smear positive TB patients from Gondar, Ethiopia (n = 180) were randomized to a food supplementation rich in arginine (peanuts, equivalent to 1 g of arginine/day) or with a low arginine content (wheat crackers, locally called daboqolo) during four weeks. The primary outcome was cure rate according to the WHO classification and secondary outcomes were sputum smear conversion, weight gain, sedimentation rate, reduction of cough and chest X-ray improvement as well as levels of NO in urine (uNO) or exhaled air (eNO) at two months. There was no effect of the intervention on the primary outcome (OR 1.44, 95% CI: 0.69-3.0, p = 0.39) or secondary outcomes. In the subgroup analysis according to HIV status, peanut supplemented HIV+/TB patients showed increased cure rate (83.8% (31/37) vs 53.1% (17/32), p < 0.01). A low baseline eNO (<10 ppb) in HIV+/TB patients was associated with a decreased cure rate. We conclude that nutritional supplementation with a food supplement rich in arginine did not have any overall clinical effect. In the subgroup of HIV positive TB patients, it significantly increased the cure rate and as an additional finding in this subgroup, low initial levels of NO in exhaled air were associated with a poor clinical outcome but this needs to be confirmed in further studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Nepal 1 <1%
Ecuador 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Unknown 109 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 16%
Researcher 15 13%
Student > Bachelor 13 11%
Student > Ph. D. Student 12 10%
Other 8 7%
Other 20 17%
Unknown 29 25%
Readers by discipline Count As %
Medicine and Dentistry 33 28%
Social Sciences 14 12%
Agricultural and Biological Sciences 12 10%
Nursing and Health Professions 6 5%
Immunology and Microbiology 4 3%
Other 17 15%
Unknown 30 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2011.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Tuberculosis (formerly Tubercle and Lung Disease)
#417
of 1,599 outputs
Outputs of similar age
#46,663
of 130,293 outputs
Outputs of similar age from Tuberculosis (formerly Tubercle and Lung Disease)
#5
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,599 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,293 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.